British journal of obstetrics and gynaecology · 1997
Use of oral misoprostol in the prevention of postpartum haemorrhage.
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el-Refaey H, O'Brien P, Morafa W, Walder J, Rodeck C
Аннотация
OBJECTIVE: To investigate the use of the oral prostaglandin E1 analogue, misoprostol in the prevention of postpartum haemorrhage.
DESIGN: A prospective observational study.
SETTING: A university teaching hospital.
PARTICIPANTS: Two hundred and thirty-seven consecutive women undergoing vaginal delivery.
METHODS: All the women were given 600 micrograms oral misoprostol just after delivery.
MAIN OUTCOME MEASURES: Rates of postpartum haemorrhage; need for therapeutic oxytocic drugs; retained placenta and length of the third stage of labour.
RESULTS: Postpartum haemorrhage occurred in 6% of the women; the need for therapeutic oxytocics in 5%, retained placenta in 2% and the median length of the third stage was 5 min. Vomiting and diarrhoea in the first hour after delivery occurred in 8% and 3% respectively and shivering in 60%.
CONCLUSIONS: Misoprostol may be effective in the prevention of postpartum haemorrhage, and has few side effects. A double blind randomised trial is required.
DESIGN: A prospective observational study.
SETTING: A university teaching hospital.
PARTICIPANTS: Two hundred and thirty-seven consecutive women undergoing vaginal delivery.
METHODS: All the women were given 600 micrograms oral misoprostol just after delivery.
MAIN OUTCOME MEASURES: Rates of postpartum haemorrhage; need for therapeutic oxytocic drugs; retained placenta and length of the third stage of labour.
RESULTS: Postpartum haemorrhage occurred in 6% of the women; the need for therapeutic oxytocics in 5%, retained placenta in 2% and the median length of the third stage was 5 min. Vomiting and diarrhoea in the first hour after delivery occurred in 8% and 3% respectively and shivering in 60%.
CONCLUSIONS: Misoprostol may be effective in the prevention of postpartum haemorrhage, and has few side effects. A double blind randomised trial is required.