F&S reports · 2021
Molar pregnancy after in vitro fertilization with euploid single embryo transfer.
СтатьяНазвание и аннотация: Перевод в очереди
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Zhou Beth, Anglin Helen Paige, Quaas Alexander M
Аннотация
OBJECTIVE: To describe a case of molar pregnancy after in vitro fertilization (IVF) resulting from the transfer of a euploid embryo derived from a monopronuclear zygote.
DESIGN: Case report and review of the literature.
SETTING: Private practice IVF center.
PATIENTS: A 42-year-old woman, gravida 3 para 0, with advanced maternal age and infertility who underwent IVF.
INTERVENTIONS: Preimplantation genetic testing for aneuploidy using next-generation sequencing, single frozen euploid blastocyst transfer, and medical management of suspected missed abortion.
MAIN OUTCOME MEASURES: Genetic examination of products of conception and correlation with embryonic preimplantation genetic testing for aneuploidy results.
RESULTS: Transfer of the euploid embryo derived from an abnormally fertilized oocyte (monopronuclear zygote) resulted in a clinical pregnancy suspected to be a missed abortion. Products of conception collected after medical management of the suspected missed abortion were analyzed using next-generation sequencing with the report "46,XX complete molar pregnancy".
CONCLUSIONS: To our knowledge, this is the first account of a complete molar pregnancy resulting from the transfer of a reported euploid embryo, highlighting the importance of understanding the limitations of genetic testing platforms in the setting of abnormally fertilized oocyte-derived embryos.
DESIGN: Case report and review of the literature.
SETTING: Private practice IVF center.
PATIENTS: A 42-year-old woman, gravida 3 para 0, with advanced maternal age and infertility who underwent IVF.
INTERVENTIONS: Preimplantation genetic testing for aneuploidy using next-generation sequencing, single frozen euploid blastocyst transfer, and medical management of suspected missed abortion.
MAIN OUTCOME MEASURES: Genetic examination of products of conception and correlation with embryonic preimplantation genetic testing for aneuploidy results.
RESULTS: Transfer of the euploid embryo derived from an abnormally fertilized oocyte (monopronuclear zygote) resulted in a clinical pregnancy suspected to be a missed abortion. Products of conception collected after medical management of the suspected missed abortion were analyzed using next-generation sequencing with the report "46,XX complete molar pregnancy".
CONCLUSIONS: To our knowledge, this is the first account of a complete molar pregnancy resulting from the transfer of a reported euploid embryo, highlighting the importance of understanding the limitations of genetic testing platforms in the setting of abnormally fertilized oocyte-derived embryos.