Molar pregnancy after in vitro fertilization with euploid single embryo transfer.

OBJECTIVE

To describe a case of molar pregnancy after in vitro fertilization (IVF) resulting from the transfer of a euploid embryo derived from a monopronuclear zygote.

DESIGN

Case report and review of the literature.

SETTING

Private practice IVF center.

PATIENTS: A 42-year-old woman, gravida 3 para 0, with advanced maternal age and infertility who underwent IVF.

INTERVENTIONS: Preimplantation genetic testing for aneuploidy using next-generation sequencing, single frozen euploid blastocyst transfer, and medical management of suspected missed abortion.

MAIN OUTCOME MEASURES: Genetic examination of products of conception and correlation with embryonic preimplantation genetic testing for aneuploidy results.

RESULTS

Transfer of the euploid embryo derived from an abnormally fertilized oocyte (monopronuclear zygote) resulted in a clinical pregnancy suspected to be a missed abortion. Products of conception collected after medical management of the suspected missed abortion were analyzed using next-generation sequencing with the report "46,XX complete molar pregnancy".

CONCLUSIONS

To our knowledge, this is the first account of a complete molar pregnancy resulting from the transfer of a reported euploid embryo, highlighting the importance of understanding the limitations of genetic testing platforms in the setting of abnormally fertilized oocyte-derived embryos.