Real-time Subgrouping of Sepsis and Systemic Inflammatory Syndromes.

Biological heterogeneity in sepsis and related systemic inflammatory syndromes has constrained therapeutic advancement and reduced the efficiency of conventional trial designs. Reproducible host response-derived sepsis subgroups recur across clinical, protein biomarker-based, and transcriptomic dimensions. A practical route to the implementation and evaluation of real-time subgrouping is a 2-stage pipeline that combines assessment of sepsis subgroup eligibility with subsequent classification. Priorities for future work are embedding classifiers and diagnostic platforms with high validity into clinical workflow so that prospective clinical trials can test their clinical utility.