Fertility and sterility · 2009
Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Noyes Nicole, Perretta Rosanna C, Fino M Elizabeth, Matulewicz Theodore, Barakat Richard
Аннотация
OBJECTIVE: To describe a case of ovarian luteinized thecoma, a rare ovarian neoplasm, which is only the 26th reported case associated with sclerosing peritonitis.
DESIGN: Case report.
SETTING: NYU Fertility Center and Memorial Hospital for Cancer and Allied Diseases, New York.
PATIENT(S): A 17-year-old woman presenting with a large pelvic mass and abdominal pain.
INTERVENTION(S): Conservative surgical treatment with laparotomy, unilateral salpingooophorectomy, and biopsy of contralateral ovary. Gonadotropin-releasing hormone agonist suppression. Ovarian hyperstimulation with oocyte retrieval/freezing to preserve biologic fertility.
MAIN OUTCOME MEASURE(S): Response to conservative therapy and oocyte cryopreservation as a method of fertility preservation.
RESULT(S): At laparotomy, obvious unilateral ovarian involvement was present, and a left salpingoophorectomy was performed. Biopsy of the contralateral ovary confirmed bilateral disease. The initial pathological review was complicated by extensive ovarian edema. The patient was treated with gonadotropin-releasing hormone agonist suppression plus intermittent estradiol supplementation. When she became intolerant of hormone therapy and when removal of the remaining ovary became a possibility, she underwent ovarian hyperstimulation; oocyte retrieval and freezing were performed to preserve her biologic fertility. Thirty-eight eggs were obtained.
CONCLUSION(S): Surgically diagnosed luteinized thecoma can be managed medically. Oocyte cryopreservation as a means of fertility preservation should be considered in young women with this diagnosis who are at risk for bilateral gonad removal.
DESIGN: Case report.
SETTING: NYU Fertility Center and Memorial Hospital for Cancer and Allied Diseases, New York.
PATIENT(S): A 17-year-old woman presenting with a large pelvic mass and abdominal pain.
INTERVENTION(S): Conservative surgical treatment with laparotomy, unilateral salpingooophorectomy, and biopsy of contralateral ovary. Gonadotropin-releasing hormone agonist suppression. Ovarian hyperstimulation with oocyte retrieval/freezing to preserve biologic fertility.
MAIN OUTCOME MEASURE(S): Response to conservative therapy and oocyte cryopreservation as a method of fertility preservation.
RESULT(S): At laparotomy, obvious unilateral ovarian involvement was present, and a left salpingoophorectomy was performed. Biopsy of the contralateral ovary confirmed bilateral disease. The initial pathological review was complicated by extensive ovarian edema. The patient was treated with gonadotropin-releasing hormone agonist suppression plus intermittent estradiol supplementation. When she became intolerant of hormone therapy and when removal of the remaining ovary became a possibility, she underwent ovarian hyperstimulation; oocyte retrieval and freezing were performed to preserve her biologic fertility. Thirty-eight eggs were obtained.
CONCLUSION(S): Surgically diagnosed luteinized thecoma can be managed medically. Oocyte cryopreservation as a means of fertility preservation should be considered in young women with this diagnosis who are at risk for bilateral gonad removal.