[The clinical significance of pvuii polymorphism estradiol receptor alpha gene to improve diagnosis of proliferative forms of benign breast dysplasia].

The aim - to determine the role of single nucleotide polymorphism PvuII of the gene EsRα as an indicator of proliferative activity in benign breast dysplasia (BBD) and its effect on receptor status of breast tissue for expression EsRα. Defined genotype PvuII polymorphism EsRα, the expression level in remote EsRα among patients with BBD. For these patients, and morphological parameters samples are divided into groups and compared. It is shown that there is a connection between the PvuII-gene polymorphism EsRα with the degree of proliferation (χ2=43,142; p<0,0001) and the expression level EsRα (χ2=51,041; p<0,0001) in breast tissue at BBD in patients with homozygous (C/C) polymorphism PvuІІ of the gene EsRα. Addition to the standard morphological study justified immunohistochemical study with the definition of the expression level of EsRα due to the fact that the increase in the level of expression associated with an increase in cell proliferation in tumors with BBD (χ2=7,370; p=0,007). An algorithm for the diagnosis of proliferative forms BBD.