[Characteristics of the effect of drug combinations on the development of immediate hypersensitivity].

As compared to the action of the drugs given alone, the combinations of antiallergic drugs and cardiac glycosides had different effects on the nature and intensity of the processes inherent in allergy. These differences correlated to a certain degree with the mechanism of a reaction which experienced the action of the drug combination. Within the frames of synergoantagonism interplay, the drug combination produced on some of the reactions an effect which was similar to that exerted by one of the components. Meanwhile the magnitude of the effect produced by the same drug combination on the other reactions was half as that manifested by the components administered alone. Sometimes in the combinations of the drugs, the effects of the constituent parts were perversed in the course of action on some of the processes. In individual cases the combined drugs had remarkable effects on a reaction, while the individual components did not change it. Strophanthine given in the combinations tested, almost never displayed its specific action on the reactions inherent in sensitization. Combined diphenhydramine affected, as a rule, the sensitization and altered the effect of other substances.