Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in multiple myeloma.

BACKGROUND

Vaginal Birth After Cesarean delivery (VBAC) is widely regarded as one of the most effective methods to reduce unnecessary Cesarean section and their complications. Despite its proven benefits, data on the success rate of VBAC and the associated factors remain scarce in Afghanistan. This study aimed to address this gap by determining the VBAC success rate and identifying its associated factors in a maternity hospital in Kabul, Afghanistan.

METHODS

This cross-sectional study was conducted at Malalai Obstetrics and Gynecology Hospital in Kabul, Afghanistan. The study sample included women with a history of previous cesarean section who visited the hospital between March 21 and September 22, 2023. Demographic and clinical information were collected from client files. Descriptive statistics were used to summarize the demographic and clinical characteristics of the study sample. The association between VBAC and various categorical variables were examined using chi-square tests, with a significance level set at p < 0.05. Logistic regression analysis was performed to identify independent predictors of VBAC, with VBAC as the outcome variable and multiple predictors included in the model.

RESULTS

Among the 567 women included in the study, 449 (79.2%) had a successful VBAC. Factors associated with successful VBAC and their adjusted odds ratio (95% CI) were lower gestational age: 1.25 (1.05-1.48), absence of gestational hypertension: 2.71 (1.26-5.85), cervical dilation of > 4 cm on admission: 2.77 (1.38-5.55), effacement of ≥ 50% on admission: 2.13 (1.04-4.35), and absence of fetal distress: 7.35 (4.29-12.6).

CONCLUSION

The rate of successful VBAC observed in this study is at a high level (79.2%). This study is the first study to determine the VBAC success rate and its associated factors in Afghanistan. Further research is needed to validate these findings and explore additional factors influencing VBAC success.