Toxicon : official journal of the International Society on Toxinology · 2026
Comparison of two populations of the scorpion Centruroides mascota: venom composition and neutralization by a human recombinant antibody.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Gómez-Ramírez Ilse Viridiana, González-Santillán Edmundo, Romero-Moreno José Alberto, Fernández-Taboada Guillermo, Güereca Leopoldo, Zamudio Fernando, Possani Lourival D, Riaño-Umbarila Lidia, Becerril Baltazar
Аннотация
Centruroides mascota scorpion was described in 2011 by Ponce Saavedra's group as a species of medical importance in the state of Jalisco. In this study, we characterized two populations of scorpions collected in the states of Jalisco and Nayarit. Through a morphometric analysis, the determination of the LD50 of the respective venoms, electrophoresis, separation of their components by HPLC, mass spectrometry, and neutralization tests, it has been possible to establish that they correspond to the same species, distributed in different habitats. The scFv 10FG2 antibody fragment, which shows broad cross-neutralization of various scorpion toxins, was evaluated for the first time in the recognition of toxins from this venom and in its neutralization. The recombinant antibody fragment 10FG2 neutralizes 2 LD50 of venom of Centruroides mascota from both localities.