Медицинская библиотека · Future microbiology · 2025

Chlorpromazine, impregnated in foley catheter fragments, as an antibiofilm agent to control urinary tract infections.

Amando Bruno Rocha, Sidrim José Júlio Costa, Firmiano Gomes Francisco Ivanilsom, Melgarejo Carliane Melo, de Souza Paulo Roberto Honório, de Medeiros Guedes Rodrigo Fonseca, Dantas Júnior Vicente Maciel, Monteiro Portela Fernando Victor, de Melo Guedes Glaucia Morgana, de Aguiar Cordeiro Rossana, Gadelha Rocha Marcos Fábio, de Souza Collares Maia Castelo-Branco Débora, Pereira de Sousa Paulo César, Riello Giovanna Barbosa

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Аннотация

BACKGROUND

The study proposes to evaluate the impregnation of Foley catheters, in different concentrations of CPZ, to control the formation of biofilms in vitro by the uropathogens most commonly associated with indwelling catheters.

MATERIALS &

METHODS

Minimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ (at different concentrations) on biofilm formation were evaluated. Biofilm formation and the effect of CIP and MER on mature biofilms in CPZ-impregnated catheters were evaluated.

RESULTS

The CPZ MIC was 312.5-625 µg/ml. CPZ significantly (p < 0.05) disrupted biofilm formation at all tested concentrations. In addition, the tested CPZ potentiated the action of CIP.

CONCLUSIONS

Our results suggest the use of CPZ by impregnation of catheters can prevent the formation of bacterial biofilms, preventing urinary infections through this route.

Для цитирования: Amando Bruno Rocha, Sidrim José Júlio Costa, Firmiano Gomes Francisco Ivanilsom, Melgarejo Carliane Melo, de Souza Paulo Roberto Honório, de Medeiros Guedes Rodrigo Fonseca, Dantas Júnior Vicente Maciel, Monteiro Portela Fernando Victor, de Melo Guedes Glaucia Morgana, de Aguiar Cordeiro Rossana, Gadelha Rocha Marcos Fábio, de Souza Collares Maia Castelo-Branco Débora, Pereira de Sousa Paulo César, Riello Giovanna Barbosa. Chlorpromazine, impregnated in foley catheter fragments, as an antibiofilm agent to control urinary tract infections.. Future microbiology. 2025. DOI: 10.1080/17460913.2025.2572902.

Предметные рубрики MeSH

Biofilms Urinary Tract Infections Microbial Sensitivity Tests Humans Chlorpromazine Urinary Catheters Anti-Bacterial Agents Catheter-Related Infections Urinary Catheterization Catheters, Indwelling

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