Termination of pregnancy with vaginal administration of 16, 16 dimethyl prostaglandin E2 p-benzaldehyde semicarbazone ester.

A 16,16 dimethyl prostaglandin E2 p-benzaldehyde semicarbazone ester was used for termination of pregnancy in 54 late first trimester and second trimester patients. The drug (750 microng in gelatine glycerine pessaries) was administered every four hours. Fifty patients (92-5%) aborted during the 36 hours treatment. Side effects were mild and consisted of vomiting in five patients, diarrhoea in three patients and transient pyrexia in two.