Progress in neuro-psychopharmacology & biological psychiatry · 2009
Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.
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Vinberg Maj, Mellerup Erling, Andersen Per Kragh, Bennike Bente, Kessing Lars Vedel
Аннотация
BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders.
AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol.
METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers.
RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol.
CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.
AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol.
METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers.
RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol.
CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.
Предметные рубрики MeSH
AdultDiseases in TwinsFamily HealthFemaleGenetic Predisposition to DiseaseHumansHydrocortisoneLife Change EventsMaleMiddle AgedMood DisordersMultivariate AnalysisNeurotic DisordersPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSelf ConceptSerotonin Plasma Membrane Transport ProteinsTwin Studies as TopicTwins