Acta paediatrica (Oslo, Norway : 1992) · 2026
Neonatal Seizures Were Associated With Higher Mortality, Epilepsy and Cerebral Palsy in Term-Born Children up to 5 Years of Age.
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Lappegård Jostein, Lyeng Ulrik Båtstrand, Støen Ragnhild, Moster Dag, Vatne Anlaug, Nordvik Tone, Eriksen Beate Horsberg, Fagerli Ingebjørg, Rønnestad Arild Erland, Klingenberg Claus
Аннотация
AIM: This study described the aetiological factors associated with neonatal seizures and the risks for adverse neurological outcomes.
METHODS: We identified all infants born at ≥ 36 weeks of gestation between 2009 and 2015 who were diagnosed with or treated for neonatal seizures and registered in the Norwegian Neonatal Network. Data from four nationwide registries provided information on perinatal factors and neurological outcomes until 5 years of age.
RESULTS: There were 892 infants with seizures, which was an incidence of 2.2 per 1000 live births. More than half (58.5%) underwent electroencephalography monitoring and examinations. Mortality before discharge was 8.4% and deaths occurred a median of 5 days after birth. The most frequent presumed aetiology for neonatal seizures was moderate to severe hypoxic-ischaemic encephalopathy (25.1%). Of the 817 survivors, 115 (14.1%) were diagnosed with post-neonatal epilepsy, 119 (14.6%) with cerebral palsy (CP), and 43 (5.3%) had both diagnoses. The epilepsy risk was greatest after neonatal encephalopathy with normal Apgar scores (40.9%) and the CP risk was greatest after an ischaemic stroke (29.9%).
CONCLUSION: Neonatal seizures were associated with a high risk of mortality and about a quarter were later diagnosed with epilepsy and/or CP. Improved access to electroencephalography and higher usage could improve diagnostics.
METHODS: We identified all infants born at ≥ 36 weeks of gestation between 2009 and 2015 who were diagnosed with or treated for neonatal seizures and registered in the Norwegian Neonatal Network. Data from four nationwide registries provided information on perinatal factors and neurological outcomes until 5 years of age.
RESULTS: There were 892 infants with seizures, which was an incidence of 2.2 per 1000 live births. More than half (58.5%) underwent electroencephalography monitoring and examinations. Mortality before discharge was 8.4% and deaths occurred a median of 5 days after birth. The most frequent presumed aetiology for neonatal seizures was moderate to severe hypoxic-ischaemic encephalopathy (25.1%). Of the 817 survivors, 115 (14.1%) were diagnosed with post-neonatal epilepsy, 119 (14.6%) with cerebral palsy (CP), and 43 (5.3%) had both diagnoses. The epilepsy risk was greatest after neonatal encephalopathy with normal Apgar scores (40.9%) and the CP risk was greatest after an ischaemic stroke (29.9%).
CONCLUSION: Neonatal seizures were associated with a high risk of mortality and about a quarter were later diagnosed with epilepsy and/or CP. Improved access to electroencephalography and higher usage could improve diagnostics.