Revista brasileira de ortopedia · 2024
Botulinum Toxin's Effects on Muscle Tone and Joint Mobility in Children with Congenital Zika Syndrome - A Case Series.
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Silva Patrícia Juliana da, Brito Ana Stela Salvino de, Silva Mariana Balbino da, Barros Nathalia Nogueira Romariz, Tavares Jousilene Sales, Gama Gabriela Lopes
Аннотация
Objective To evaluate the effects of the botulinum toxin (BTX-A) on muscle tone and joint mobility in children with congenital Zika syndrome (CZS). Methods This was a longitudinal case series carried out in a Support Center for Children with Microcephaly, located in Northeastern Brazil. We collected data from the institution's medical records, containing information about muscle tone and passive joint mobility measured at least 3 months before and 4 weeks after BTX-A application. Results We evaluated 13 children (9 boys) with a mean age of 77 ± 7.1 months. After BTX-A application, a bilateral reduction in the hypertonia level was observed in the elbow flexor ( p < 0.01) and hip abductor ( p < 0.05) muscles. Conclusion No changes were observed in joint mobility and no adverse effects were reported by caregivers after application. The use of BTX-A can reduce hypertonia in CZS children, with no impact on joint mobility.