Beyond anaphylaxis: a multidimensional exploration of sesame allergy in a globalized world.

Sesame (Sesamum indicum) seeds offers a varieties of health benefits, which include protection against hypertension, cognitive decline, diabetes, and anti-inflammatory properties. However, sesame allergy is becoming as a significant global health concern, primarily driven by IgE-mediated reactions that can ranges from mild symptoms to severe anaphylaxis. So far, seven sesame allergens have been officially recognized by the World Health Organization and the International Union of Immunological Societies. This article highlights the characteristics and universal prevalence of these allergens, the underling, pathophysiology and recent advances in detection techniques such as biosensors, mass spectrometry, immunopathology and nucleic acid-based methods. This review serves as a gateway for further research and supports the development of hypoallergenic sesame products.