SCOPE: Surveillance of COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020.
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Kumar Sunesh, Bhatla Neerja, Sharma K Aparna, Agarwal Ramesh, Verma Ankit, Perumal Vanamail, Shiv Kumar Poonam, Garg B S, Goudar Shivaprasad S, Pujar Yeshita V, Kavi Avinash, Suri Vanita, Joshi Bharti, Rathore Asmita, Gupta Madhavi M, Kumar Ajay, Puri Manju, Meena Deepika, Nangia Sushma, Arora Renu, Bachani Sumitra, Anand Pratima, Seth Shikha, Gupta Rakesh, Sehgal Rohini, Rana Anubhuti, Kumari Archana, P Shainy, Donimath Kasturi, Gowder Guruprasad, Kedar Lakshmi, Kar Tushar, Mishra Sujata, Joshi Chinmayi, Kabade Yogendra, Kamatar Saroja, Nanda Saumya, Mohapatra Vandana, Vellanki Janki, Agarwal Sarita, Borkar Aparna Wahane, Kumar Aruna, Sultan Shabana, Gangane Neha, Chaudhary Pushpa, Jayathilaka Anoma, Raina Neena, Karna Priya, SCOPE Study Group
Аннотация
DESIGN: Multicentric case-control study.
DATA SOURCES: Ambispective primary data collection through paper-based forms from 20 tertiary care centres across India between April and November 2020.
STUDY POPULATION: All pregnant women reporting to the centres with a lab-confirmed COVID-19 positive result matched with controls.
DATA QUALITY: Dedicated research officers extracted hospital records, using modified WHO Case Record Forms (CRF) and verified for completeness and accuracy.
STATISTICAL ANALYSIS: Data converted to excel files and statistical analyses done using STATA 16 (StataCorp, TX, USA). Odds ratios (ORs) with 95% confidence intervals (CI) estimated using unconditional logistic regression.
RESULTS: A total of 76,264 women delivered across 20 centres during the study period. Data of 3723 COVID positive pregnant women and 3744 age-matched controls was analyzed. Of the positive cases 56·9% were asymptomatic. Antenatal complications like preeclampsia and abruptio placentae were seen more among the cases. Induction and caesarean delivery rates were also higher among Covid positive women. Pre-existing maternal co-morbidities increased need for supportive care. There were 34 maternal deaths out of the 3723(0.9%) positive mothers, while covid negative deaths reported from all the centres were 449 of 72,541 (0·6%).
CONCLUSION: Covid-19 infection predisposed to adverse maternal outcomes in a large cohort of Covid positive pregnant women as compared to the negative controls.