Медицинская библиотека · Journal of global antimicrobial resistance · 2019

Drug susceptibility profile of Mycobacterium kansasii clinical isolates from Brazil.

de Carvalho Luciana Distásio, de Queiroz Mello Fernanda Carvalho, Redner Paulo, Campos Carlos Eduardo Dias, de Souza Caldas Paulo Cesar, da Silva Lourenço Maria Cristina, Ramos Jesus Pais

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVES

Mycobacterium kansasii (M. kansasii) pulmonary infection can cause disease with clinical and radiological features similar to tuberculosis. Failure to treat M. kansasii infection is usually associated with resistance; to increase the chance of successful treatment it is important to identify the species and know the susceptibility profile. This study aimed to evaluate the antimycobacterial susceptibility profiles of M. kansasii isolates from Brazil.

METHODS

Sixty-nine M. kansasii isolates from 69 patients were identified by partial sequencing of the hsp65 gene, and their susceptibility profiles were analysed by minimal inhibitory concentration (MIC) assays.

RESULTS

From 69 isolates, 68 showed susceptibility to clarithromycin, amikacin, and moxifloxacin. Most strains showed high rates of resistance to trimethoprim-sulfamethoxazole and ciprofloxacin. Resistance to rifampicin and ethambutol was found in 12% and 25% of isolates, respectively.

CONCLUSIONS

Worrying results were found regarding susceptibility to some drugs used as first-line agents in the treatment of diseases caused by M. kansasii.

Для цитирования: de Carvalho Luciana Distásio, de Queiroz Mello Fernanda Carvalho, Redner Paulo, Campos Carlos Eduardo Dias, de Souza Caldas Paulo Cesar, da Silva Lourenço Maria Cristina, Ramos Jesus Pais. Drug susceptibility profile of Mycobacterium kansasii clinical isolates from Brazil.. Journal of global antimicrobial resistance. 2019. DOI: 10.1016/j.jgar.2019.05.003.

Предметные рубрики MeSH

Anti-Bacterial Agents Bacterial Proteins Brazil Chaperonin 60 Drug Resistance, Multiple, Bacterial Humans Microbial Sensitivity Tests Mycobacterium Infections, Nontuberculous Mycobacterium kansasii

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