The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2017
Outcome of dichorionic triamniotic triplet: the experience from an emerging fetal therapy center.
СтатьяНазвание и аннотация: Перевод в очереди
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Sun Luming, Zou Gang, Zhou Fenhe, Yang Yingjun, Oepkes Dick, Duan Tao
Аннотация
OBJECTIVES: To report a cohort of dichorionic triamniotic (DCTA) triplets with access to contemporary fetal interventions.
DESIGN: Prospective study.
SETTING: A regional referral center for the diagnosis and management of complicated multiple pregnancies.
POPULATION: All DCTA triplets receiving consultation and prenatal care at our center from 2010 to 2015.
METHODS: The following management alternatives for DCTA were offered: 1) expectant management; 2) reduction of one or two fetus of the monochorionic (MC) component using radiofrequency ablation (RFA) after 16 weeks or potassium chloride (KCL) before 16 weeks, respectively; 3) reduction of the isolated fetus using KCL before 16 weeks.
MAIN OUTCOME MEASURE: Survival rate of different management alternatives.
RESULTS: A total of 47 DCTA triplets were included in this study. After consultations on possible prognosis and management options, 19 patients chose expectant management, 14 patients opted RFA to reduce one fetus of the MC component, 14 patients required KCL to reduce the MC component. Fetal demise per pregnancy occurred more frequently in the subgroup managed expectantly (53%) compared to subgroups managed with RFA (7%, p = .02) or KCL (0%, p = .02). Overall survival was significantly lower in DCTA triplets managed expectantly (58%) compared to subgroup managed with RFA (93%, p < .01) or KCL (100%, p = .04).
CONCLUSION: Fetal reduction seems to improve perinatal survival in DCTA triplets.
DESIGN: Prospective study.
SETTING: A regional referral center for the diagnosis and management of complicated multiple pregnancies.
POPULATION: All DCTA triplets receiving consultation and prenatal care at our center from 2010 to 2015.
METHODS: The following management alternatives for DCTA were offered: 1) expectant management; 2) reduction of one or two fetus of the monochorionic (MC) component using radiofrequency ablation (RFA) after 16 weeks or potassium chloride (KCL) before 16 weeks, respectively; 3) reduction of the isolated fetus using KCL before 16 weeks.
MAIN OUTCOME MEASURE: Survival rate of different management alternatives.
RESULTS: A total of 47 DCTA triplets were included in this study. After consultations on possible prognosis and management options, 19 patients chose expectant management, 14 patients opted RFA to reduce one fetus of the MC component, 14 patients required KCL to reduce the MC component. Fetal demise per pregnancy occurred more frequently in the subgroup managed expectantly (53%) compared to subgroups managed with RFA (7%, p = .02) or KCL (0%, p = .02). Overall survival was significantly lower in DCTA triplets managed expectantly (58%) compared to subgroup managed with RFA (93%, p < .01) or KCL (100%, p = .04).
CONCLUSION: Fetal reduction seems to improve perinatal survival in DCTA triplets.
Предметные рубрики MeSH
AdultBirth WeightFemaleFetal DeathPremature Rupture of Fetal MembranesGestational AgeHumansInfant, NewbornPotassium ChloridePregnancyPregnancy Reduction, MultifetalPregnancy, High-RiskPregnancy, TripletProspective StudiesRadiofrequency AblationSurvival AnalysisUltrasonography, PrenatalWatchful Waiting