Archives of physiology and biochemistry · 2026
Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways.
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Zahran Faten, Barakat Nashwa, Ismail Ehab, Khirallah Salma M
Аннотация
AIM: The objective of this study was to assess the protective effects of melatonin (Mel) and selenium nanoparticles (SeNPs) against cisplatin (Cis)-induced nephrotoxicity in rats.
METHODS: Sixty male rats were categorised into five groups: Control, Cis, Cis + Mel, Cis + SeNPs, and Cis + Mel + SeNPs. Kidney injury was evaluated at 5 and 11 days using biochemical markers, oxidative stress indicators, gene expression analysis as well as histopathological and immunohistochemical assessments.
RESULTS: The combined treatment of Mel + SeNPs significantly improved kidney function biomarkers, reduced MDA levels, increased the activities of SOD, CAT, and GSH, decreased the expression of Bax and IL-6, and increased the expression of Bcl-2, Nrf2, and HO-1 compared to Cis group (p < 0.05). The histological structure and protein expression profiles indicated the most significant enhancement in the combined therapy group, especially on day 11.
CONCLUSION: The co-administration of Mel and SeNPs demonstrated a significant synergistic effect in protecting the kidneys from Cis-induced nephrotoxicity.
METHODS: Sixty male rats were categorised into five groups: Control, Cis, Cis + Mel, Cis + SeNPs, and Cis + Mel + SeNPs. Kidney injury was evaluated at 5 and 11 days using biochemical markers, oxidative stress indicators, gene expression analysis as well as histopathological and immunohistochemical assessments.
RESULTS: The combined treatment of Mel + SeNPs significantly improved kidney function biomarkers, reduced MDA levels, increased the activities of SOD, CAT, and GSH, decreased the expression of Bax and IL-6, and increased the expression of Bcl-2, Nrf2, and HO-1 compared to Cis group (p < 0.05). The histological structure and protein expression profiles indicated the most significant enhancement in the combined therapy group, especially on day 11.
CONCLUSION: The co-administration of Mel and SeNPs demonstrated a significant synergistic effect in protecting the kidneys from Cis-induced nephrotoxicity.