International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2008
Impact of prolonged referral interval on colposcopic outcomes in women with moderate or severe dysplasia.
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Fakokunde Biodun, Selo-Ojeme Dan
Аннотация
OBJECTIVE: To ascertain the impact of long referral to first colposcopy interval on disease outcome in women with high-grade cervical smear tests.
METHODS: Data from 316 women categorized into Group 1 (seen 180 days after referral) and Group 2 (seen within 180 days of referral) were analyzed using chi2 test with Yates correction. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
RESULTS: Women in Group 1 were less likely to need treatment (33.8% [25/74] vs 55.8% [135/242]; OR=0.45; 95% CI, 0.25-0.78; P=0.0004) and less likely to have high-grade disease (24.3% [18/74] vs 45.9% [111/242]); OR=0.37; 95% CI, 0.21-0.68; P=0.001) than women in Group 2. There was no significant difference between the groups in proportion of women with invasive disease.
CONCLUSION: In women with high-grade smears the need for excisional treatment and the risk of invasive disease may be reduced by prolonged referral interval.
METHODS: Data from 316 women categorized into Group 1 (seen 180 days after referral) and Group 2 (seen within 180 days of referral) were analyzed using chi2 test with Yates correction. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.
RESULTS: Women in Group 1 were less likely to need treatment (33.8% [25/74] vs 55.8% [135/242]; OR=0.45; 95% CI, 0.25-0.78; P=0.0004) and less likely to have high-grade disease (24.3% [18/74] vs 45.9% [111/242]); OR=0.37; 95% CI, 0.21-0.68; P=0.001) than women in Group 2. There was no significant difference between the groups in proportion of women with invasive disease.
CONCLUSION: In women with high-grade smears the need for excisional treatment and the risk of invasive disease may be reduced by prolonged referral interval.