Indian journal of psychiatry · 2026
A study of positive and negative factors associated with tapering off methadone maintenance treatment.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kumar Kishor, Shekhawat Bharat S, Yadav Sandhya, Gothwal Rohitashava, Rangrez Mohammed A
Аннотация
BACKGROUND AND AIM: Evidence on factors associated with successful methadone tapering in India is limited. This study aims to identify positive and negative factors associated with successful tapering of methadone maintenance treatment (MMT).
MATERIALS AND METHODS: This retrospective study reviewed records of 88 patients undergoing MMT tapering at a tertiary care drug treatment clinic (DTC). Demographic, clinical, withdrawal, motivational, and treatment-related factors associated with taper outcomes were analyzed.
RESULTS: Seventeen participants (19.3%) successfully completed tapering without relapse. Successful tapering was associated with lower baseline methadone dose, lower withdrawal severity, greater motivation, and absence of tobacco use. Participants who relapsed after taper completion had significantly higher taper rates than those who remained abstinent (6.4 vs. 3.3 mg/week; P = 0.039). Fear of relapse, withdrawal symptoms, family instability, economic instability, and fear of death were common barriers to tapering.
CONCLUSION: Successful tapering was associated with lower baseline methadone dose, slower taper rate, lower withdrawal severity, greater motivation, and absence of tobacco use.
MATERIALS AND METHODS: This retrospective study reviewed records of 88 patients undergoing MMT tapering at a tertiary care drug treatment clinic (DTC). Demographic, clinical, withdrawal, motivational, and treatment-related factors associated with taper outcomes were analyzed.
RESULTS: Seventeen participants (19.3%) successfully completed tapering without relapse. Successful tapering was associated with lower baseline methadone dose, lower withdrawal severity, greater motivation, and absence of tobacco use. Participants who relapsed after taper completion had significantly higher taper rates than those who remained abstinent (6.4 vs. 3.3 mg/week; P = 0.039). Fear of relapse, withdrawal symptoms, family instability, economic instability, and fear of death were common barriers to tapering.
CONCLUSION: Successful tapering was associated with lower baseline methadone dose, slower taper rate, lower withdrawal severity, greater motivation, and absence of tobacco use.