Prevalence and characteristics of Campylobacter from the genital tract of primates and ruminants in Eastern China.

Campylobacter infection is an important cause of genital failure in ruminants in developed countries. Although historically Campylobacter fetus subspecies fetus has been the main cause of abortion in sheep, C. jejuni is also increasingly associated with sheep abortions. However, limited information is known on Campylobacter-associated abortions in China. This study initially investigated the distribution of Campylobacter from the genital tracts of humans, monkeys, sheep and cows in China from 2017 to 2018. Ten out of 2126 (0.47%) samples from the genital tracts were Campylobacter positive, of which seven (70%) isolates were identified as C. jejuni. Phylogenetic analysis showed the high genetic diversity of these isolates. The human isolates were closely related to the sheep isolates implying inter-transmission of Campylobacter between humans and sheep according to the phylogenetic analysis. The acid resistance, adhesion and invasion abilities of genital tract isolates were stronger than isolates from gastrointestinal tract, but no significant difference was observed in the virulence genes. We further found that three genital tract isolates belonged to the same cluster as gastrointestinal isolates from the same host. These findings suggested that there may be inter-transmission of Campylobacter between the genital and gastrointestinal tract.