Journal of the American Heart Association · 2026
Association Between Maximum Temperature 24 Hours After Resuscitation and Survival for In-Hospital Cardiac Arrest.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cantu-Martinez Omar, Jawad Mohammad Abdel, Kennedy Kevin F, Girard Andrew A, Ikemura Nobuhiro, Spertus John A, Chan Paul S, American Heart Association's Get With The Guidelines–Resuscitation Investigators
Аннотация
BACKGROUND: Avoiding fever is a central tenet of postresuscitation care. However, few data exist describing the association between postresuscitation temperature and survival after in-hospital cardiac arrest, where response is usually prompt.
METHODS: Within the GWTG-Resuscitation (Get With The Guidelines-Resuscitation) registry, we identified adults from 2015 to 2024 with an index in-hospital cardiac arrest and return of spontaneous circulation who survived at least 24 hours after resuscitation. Patients were excluded if they received therapeutic hypothermia after return of spontaneous circulation to better understand the natural history of postresuscitation temperature. The primary exposure was maximum temperature 24 hours after return of spontaneous circulation, categorized by 0.5 °C intervals from <36.3 °C to ≥38.8 °C. Multivariable hierarchical logistic regression evaluated the association between maximum temperature and both survival to hospital discharge and favorable neurological survival.
RESULTS: Of 36 514 with return of spontaneous circulation, mean age was 64.2±16.6 years; 61.8% were men, and 69.4% were White individuals. Median maximum temperature was 37.2 °C (interquartile range, 36.8-37.8 °C), 66.3% survived to discharge, and 57.0% had favorable neurological survival. The highest survival (72.7%) was observed in the 36.8 to <37.3°C group (reference), with all other temperature ranges with lower rates of survival to hospital discharge (inverted U-shaped relationship), with the worst being those in the lowest (<36.3 °C, 48.4%; adjusted odds ratio, 0.42 [95% CI, 0.37-0.46]) and highest (≥38.8 °C, 51.5%; adjusted odds ratio, 0.40 [95% CI, 0.36-0.44]) ranges. A similar relationship was observed with favorable neurological survival.
CONCLUSIONS: Among patients not treated with therapeutic hypothermia, a postresuscitation temperature of 36.8 to 37.3°C after in-hospital cardiac arrest was associated with the highest survival rate, with temperatures at high and low extremes with the lowest survival.
METHODS: Within the GWTG-Resuscitation (Get With The Guidelines-Resuscitation) registry, we identified adults from 2015 to 2024 with an index in-hospital cardiac arrest and return of spontaneous circulation who survived at least 24 hours after resuscitation. Patients were excluded if they received therapeutic hypothermia after return of spontaneous circulation to better understand the natural history of postresuscitation temperature. The primary exposure was maximum temperature 24 hours after return of spontaneous circulation, categorized by 0.5 °C intervals from <36.3 °C to ≥38.8 °C. Multivariable hierarchical logistic regression evaluated the association between maximum temperature and both survival to hospital discharge and favorable neurological survival.
RESULTS: Of 36 514 with return of spontaneous circulation, mean age was 64.2±16.6 years; 61.8% were men, and 69.4% were White individuals. Median maximum temperature was 37.2 °C (interquartile range, 36.8-37.8 °C), 66.3% survived to discharge, and 57.0% had favorable neurological survival. The highest survival (72.7%) was observed in the 36.8 to <37.3°C group (reference), with all other temperature ranges with lower rates of survival to hospital discharge (inverted U-shaped relationship), with the worst being those in the lowest (<36.3 °C, 48.4%; adjusted odds ratio, 0.42 [95% CI, 0.37-0.46]) and highest (≥38.8 °C, 51.5%; adjusted odds ratio, 0.40 [95% CI, 0.36-0.44]) ranges. A similar relationship was observed with favorable neurological survival.
CONCLUSIONS: Among patients not treated with therapeutic hypothermia, a postresuscitation temperature of 36.8 to 37.3°C after in-hospital cardiac arrest was associated with the highest survival rate, with temperatures at high and low extremes with the lowest survival.