Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.
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Ошибки и ограничения
История · было → стало
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Helmy Adel, Baker Michael S, Chen Patrick M, Quinn Aoife, Jalloh Ibrahim, Roberts Louise, Badjatia Neeraj, Belli Antonio, Boutelle Martyn G, Bullock M Ross, Claassen Jan, Coles J P, Dahyot-Fizelier Claire, Ercole Ari, Foreman Brandon, Gallagher Clare, Gilmore Emily J, Gupta Arun K, Gupta Deepak, Helbok Raimund, Leroux Peter, Magnoni Sandra, Mangat Halinder S, Marklund Niklas, Mazzeo Anna Teresa, Menon David K, Nelson David W, Newcombe Virginia, Oddo Mauro, O'Phelan Kristine, Petrone Patrizio, Poca Maria A, Puccio Ava M, Robertson Claudia S, Rostami Elham, Sahuquillo Juan, Stovell Matthew G, Strong Anthony J, Svedung Wettervik Teodor, Thelin Eric P, Timofeev Ivan S, Torné Ramon, Valadka Alex, Venturini Sara, Vespa Paul, Zimphango Chisomo, Carpenter Keri L H, Chen Jefferson W, Hutchinson Peter J
Аннотация
METHODS: We conducted a 3-round modified Delphi study with international experts in CMD and neurocritical care. Consensus was defined as ≥ 75% agreement among non-abstaining respondents, with a minimum of 30 non-abstaining respondents required per statement. Statements not reaching consensus were iteratively revised based on panelist feedback.
RESULTS: Forty of 67 invited experts (60%) from 9 countries participated. Sixty of 62 individual items achieved consensus (97%) across 9 domains: indications and patient selection, technical and procedural considerations, detecting deterioration and secondary injury, metabolic interpretation, treatment algorithms, glucose management, sampling frequency, core reporting items, and barriers to clinical implementation.
CONCLUSION: This consensus statement provides updated, evidence-informed recommendations for the use of CMD in critical care. The panel reaffirmed many core recommendations from the 2014 consensus while making targeted advances: cautious extension of guidance to intracerebral hemorrhage, comprehensive reporting guidance addressing frequently omitted elements (19 items vs. 6 in 2014), and identification of 10 key barriers to routine clinical adoption.