Nature communications · 2021
Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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De Biasi Sara, Tartaro Domenico Lo, Gibellini Lara, Paolini Annamaria, Quong Andrew, Petes Carlene, Awong Geneve, Douglas Samuel, Lin Dongxia, Nieto Jordan, Galassi Francesco Maria, Borella Rebecca, Fidanza Lucia, Mattioli Marco, Leone Chiara, Neri Isabella, Meschiari Marianna, Cicchetti Luca, Iannone Anna, Trenti Tommaso, Sarti Mario, Girardis Massimo, Guaraldi Giovanni, Mussini Cristina, Facchinetti Fabio, Cossarizza Andrea
Аннотация
SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.