Virchows Archiv : an international journal of pathology · 2023
Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles.
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Bartosch Carla, Nadal Alfons, Braga Ana C, Salerno Angela, Rougemont Anne-Laure, Van Rompuy Anne-Sophie, Fitzgerald Brendan, Joyce Caroline, Allias Fabienne, Maher Geoffrey J, Turowski Gitta, Tille Jean-Christophe, Alsibai Kinan Drak, Van de Vijver Koen, McMahon Lesley, Sunde Lone, Pyzlak Michal, Downey Paul, Wessman Sandra, Patrier Sophie, Kaur Baljeet, Fisher Rosemary
Аннотация
Hydatidiform moles are rare and thus most pathologists and geneticists have little experience with their diagnosis. It is important to promptly and correctly identify hydatidiform moles given that they are premalignant disorders associated with a risk of persistent gestational trophoblastic disease and gestational trophoblastic neoplasia. Improvement in diagnosis can be achieved with uniformization of diagnostic criteria and establishment of algorithms. To this aim, the Pathology and Genetics Working Party of the European Organisation for Treatment of Trophoblastic Diseases has developed guidelines that describe the pathological criteria and ancillary techniques that can be used in the differential diagnosis of hydatidiform moles. These guidelines are based on the best available evidence in the literature, professional experience and consensus of the experts' group involved in its development.