Efficacy of deep hyperthermia on hematological parameters and tumor markers in cancer patients: a retrospective cohort study.

OBJECTIVE

To investigate the effects of deep hyperthermia on hematological parameters and tumor markers in patients with malignant tumors and to evaluate its potential adjuvant therapeutic value in improving hematopoietic and immune function.

METHODS

A retrospective analysis was conducted on 182 tumor patients who underwent deep hyperthermia at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine. A detailed deep hyperthermia treatment protocol, including tumor localization, temperature monitoring, treatment parameters and quality assurance, was strictly implemented. Hematological parameters and tumor markers were monitored dynamically during treatment. The Friedman test and a linear mixed-effects model were used for comparison and trend prediction.

RESULTS

After deep hyperthermia treatment, the Neutrophil, White blood cell count, Red blood cell count, Lymphocyte, Hemoglobin, and Platelet count were significantly increased over time (p < 0.01). At Day 56, hemoglobin increased by 12.21% and lymphocytes increased by 27.48% compared to baseline. The levels of CA153, CA724, CA242, CA50 and SCCA decreased significantly (p < 0.01). In contrast, there was no significant change in CEA, CA125 and CA199 (p > 0.05). A linear mixed-effects model predicted continued improvement in hematological parameters until Day 70.

CONCLUSION

Deep hyperthermia is associated with significantly improves hematological parameters and reduces specific tumor markers in cancer patients, with a favorable safety profile. It suggests potential benefits in enhancing immune function, correcting anemia, and reducing bleeding risk, and can serve as an effective adjuvant therapy for malignant tumors.