Diabetes technology & therapeutics · 2026
Continuous Glucose Monitoring in Pregnant Women with Type 1 Diabetes: Outcomes of a Population-Based Real-World Study.
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Price Sarah A L, Chee Melissa, Earnest Arul, Thomson Rebecca L, Penno Megan A S, Couper Jennifer J, Holmes-Walker Jane, Johnson Stephanie, Ross Glynis, Sweeting Arianne, Simmons David, Glastras Sarah, Shub Alexis, Griffin Katherine, Graham Dorothy, Duke Anna, Hg Tien-Ming, ENDIA Study Group, Jones Timothy
Аннотация
BACKGROUND: Continuous glucose monitoring (CGM) is increasingly used by women with type 1 diabetes (T1D) during pregnancy, but there are limited data on glycemic and pregnancy outcomes in large real-world cohorts.
METHODS: We collected glycemic and pregnancy outcome data from women with T1D across Australian centers between 2015 and 2025. The primary outcome was change in HbA1c from the first to the third trimester of pregnancy. Prespecified secondary outcomes included trimester-specific mean HbA1c, the proportion of women achieving HbA1c ≤6.5% (≤48 mmol/L) and ≤7.0% (≤53 mmol/L) in the third trimester, and a range of maternal and neonatal health outcomes.
RESULTS: Among 951 women, 456 (48%) were CGM users. Demographics and baseline characteristics were similar between CGM users and nonusers. For the primary outcome, adjusted linear regression models accounting for first-trimester HbA1c and insulin regimen demonstrated that CGM use was independently associated with a greater reduction in HbA1c over pregnancy (adjusted mean difference -0.20%, 95% confidence interval [CI] -0.40 to 0.00, P = 0.037). First-trimester HbA1c was the strongest predictor of HbA1c change (P < 0.001).After adjustment for first-trimester HbA1c, first-trimester body mass index, insulin regimen, parity and year of delivery, CGM use was not associated with large- or small-for-gestational-age offspring and there was no significant difference between the groups in mean birthweight. Among primiparous women, CGM use was associated with lower odds of cesarean section after adjustment for confounders (adjusted odds ratio 0.22, 95% CI 0.08-0.58, P = 0.002).
CONCLUSIONS: CGM use in pregnancy is associated with improved glycemia. The treatment effect of CGM in this real-world study is similar to that observed in the CONCEPTT study, thus supporting CGM use in pregnant women with T1D.
METHODS: We collected glycemic and pregnancy outcome data from women with T1D across Australian centers between 2015 and 2025. The primary outcome was change in HbA1c from the first to the third trimester of pregnancy. Prespecified secondary outcomes included trimester-specific mean HbA1c, the proportion of women achieving HbA1c ≤6.5% (≤48 mmol/L) and ≤7.0% (≤53 mmol/L) in the third trimester, and a range of maternal and neonatal health outcomes.
RESULTS: Among 951 women, 456 (48%) were CGM users. Demographics and baseline characteristics were similar between CGM users and nonusers. For the primary outcome, adjusted linear regression models accounting for first-trimester HbA1c and insulin regimen demonstrated that CGM use was independently associated with a greater reduction in HbA1c over pregnancy (adjusted mean difference -0.20%, 95% confidence interval [CI] -0.40 to 0.00, P = 0.037). First-trimester HbA1c was the strongest predictor of HbA1c change (P < 0.001).After adjustment for first-trimester HbA1c, first-trimester body mass index, insulin regimen, parity and year of delivery, CGM use was not associated with large- or small-for-gestational-age offspring and there was no significant difference between the groups in mean birthweight. Among primiparous women, CGM use was associated with lower odds of cesarean section after adjustment for confounders (adjusted odds ratio 0.22, 95% CI 0.08-0.58, P = 0.002).
CONCLUSIONS: CGM use in pregnancy is associated with improved glycemia. The treatment effect of CGM in this real-world study is similar to that observed in the CONCEPTT study, thus supporting CGM use in pregnant women with T1D.