[Study of the plasma adrenomedullin value in pregnancy induced hypertension patients].

OBJECTIVE

To investigate the relationship between adrenomedullin(ADM) and pregnancy induced hypertension(PIH).

METHOD: The ADM values in the plasma from 12 normal term-pregnant women and 26 women with PIH were determined by specific radioimmunoassay.

RESULT: (1) The ADM value in the PIH (24.67 +/- 1.27) ng/L increased significantly than that of normal pregnancy (19.16 +/- 1.17) ng/L (P < 0.05). (2) There were significant difference between severe(30.00 +/- 1.17) ng/L moderate (24.80 +/- 0.70) ng/L and mild (19.38 +/- 2.65) ng/L PIH groups (P < 0.001). (3) Significant positive correlation was found between plasma ADM value and mean arterial pressure (r = 0.775, P < 0.001).

CONCLUSION

The ADM level is closely associated with PIH and may plan an important role in PIH.