The American journal of gastroenterology · 2026
Previous Abdominal Surgery Is Not Associated With Adverse Pregnancy, Delivery, or Neonatal Outcomes in Women With Crohn's Disease: Results From the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes Study.
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Zurbuch Erica, Mahadevan Uma, Shah Samir, Zhang Xian, McConnell Ryan, Long Millie D
Аннотация
INTRODUCTION: Crohn's disease (CD)-related surgery may affect pregnancy outcomes.
METHODS: We used the prospective Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) cohort to investigate pregnancy outcomes among women with CD by previous surgery by bivariate and multivariate analyses.
RESULTS: Among 1,046 women with CD, 409 (39%) had previous surgery. Those with previous surgery had increased disease activity ( P < 0.001). On multivariate analysis, only disease activity (OR 1.14, 95% CI 1.06-1.22) and ileal disease (OR 2.19, 95% CI 1.26-3.83) were associated with preterm birth; not previous surgery.
DISCUSSION: Previous surgery was not associated with adverse pregnancy or neonatal outcomes in CD.
METHODS: We used the prospective Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) cohort to investigate pregnancy outcomes among women with CD by previous surgery by bivariate and multivariate analyses.
RESULTS: Among 1,046 women with CD, 409 (39%) had previous surgery. Those with previous surgery had increased disease activity ( P < 0.001). On multivariate analysis, only disease activity (OR 1.14, 95% CI 1.06-1.22) and ileal disease (OR 2.19, 95% CI 1.26-3.83) were associated with preterm birth; not previous surgery.
DISCUSSION: Previous surgery was not associated with adverse pregnancy or neonatal outcomes in CD.