ESC heart failure · 2026
Proactive Heart Failure Screening in Obesity: Design, Recruitment and Baseline Characteristics of the SCORHFE Trial.
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Motiram Praveen A, Chin Jie Fen, Rouwet Ellen V, Ter Hoeve Nienke, Brugts Jasper J, de Boer Rudolf A, van Dalen Bas M
Аннотация
BACKGROUND: Obesity is strongly associated with heart failure, but recognition remains challenging in primary care because symptoms, physical findings, and natriuretic peptide concentrations may be difficult to interpret.
OBJECTIVES: To describe the design, recruitment, baseline characteristics, and acceptability of a trial evaluating proactive multimodal heart failure screening in adults with obesity.
METHODS: Adults aged 45 years or older with obesity and no known cardiac disease were randomised 1:1 to proactive multimodal heart failure screening or usual care. Screening comprised medical history, physical examination, blood sampling, 12-lead electrocardiography, and transthoracic echocardiography. The primary endpoint is left ventricular dysfunction and/or acute heart failure hospitalisation at 1 year.
RESULTS: Between March 2024 and June 2025, 746 individuals expressed interest, 629 (84.3%) underwent eligibility assessment, and 420 were randomised. Mean age was 58.3 ± 8.4 years, 295 participants (70.2%) were women, and median body mass index was 35.0 [32.4-38.0] kg/m2. Among 385 participants with available waist circumference data, 379 (98.4%) had central obesity. Ninety-seven participants (23.1%) had two or more cardiometabolic conditions. Among a random subset of 50 screened participants, 46 (92.0%) considered screening duration acceptable, 47 (94.0%) reported low procedural burden, and 46 (92.0%) supported routine implementation.
CONCLUSIONS: Recruitment through primary care obesity pathways reached adults with substantial adiposity and cardiometabolic burden. Screening acceptability was high in a random subset. One-year follow-up will determine clinical and economic effects.
OBJECTIVES: To describe the design, recruitment, baseline characteristics, and acceptability of a trial evaluating proactive multimodal heart failure screening in adults with obesity.
METHODS: Adults aged 45 years or older with obesity and no known cardiac disease were randomised 1:1 to proactive multimodal heart failure screening or usual care. Screening comprised medical history, physical examination, blood sampling, 12-lead electrocardiography, and transthoracic echocardiography. The primary endpoint is left ventricular dysfunction and/or acute heart failure hospitalisation at 1 year.
RESULTS: Between March 2024 and June 2025, 746 individuals expressed interest, 629 (84.3%) underwent eligibility assessment, and 420 were randomised. Mean age was 58.3 ± 8.4 years, 295 participants (70.2%) were women, and median body mass index was 35.0 [32.4-38.0] kg/m2. Among 385 participants with available waist circumference data, 379 (98.4%) had central obesity. Ninety-seven participants (23.1%) had two or more cardiometabolic conditions. Among a random subset of 50 screened participants, 46 (92.0%) considered screening duration acceptable, 47 (94.0%) reported low procedural burden, and 46 (92.0%) supported routine implementation.
CONCLUSIONS: Recruitment through primary care obesity pathways reached adults with substantial adiposity and cardiometabolic burden. Screening acceptability was high in a random subset. One-year follow-up will determine clinical and economic effects.