Frontiers in pain research (Lausanne, Switzerland) · 2025
Unstimulated inflammatory activity is associated with treatment response to cognitive-behavioral therapy for urologic chronic pelvic pain.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
McKernan L C, Crofford L J, Bruehl S, McGonigle T W, Kelly A G, Ryden A M, Sutherland S L, Clauw D J, Williams D A, Dmochowski R R, Schrepf A D
Аннотация
INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating urologic chronic pelvic pain condition characterized by pelvic pain and urinary symptoms. Evidence suggests that in chronic pain conditions such as IC/BPS, inflammatory markers are associated with heightened symptom severity and widespread pain. Non-pharmacological treatments such as cognitive-behavioral therapy are recommended as a core component of IC/BPS treatment. There is limited and mixed evidence as to whether inflammatory markers are affected by non-pharmacological treatments or their relationship to treatment response. This exploratory study considered how inflammatory characteristics may both predict and explain treatment response in a sample of females with interstitial cystitis.
METHOD: Participants were randomized to receive either 8-weeks of telemedicine-delivered cognitive-behavioral therapy (CBT) or an active attention control. Six cytokine/chemokines in whole blood plasma (IL-6, IL-8, IL-10, IL-1β, and TNF-α) were assessed in a subset of trial participants at baseline, post-treatment, and at five months. We assessed relationships between baseline plasma inflammatory cytokine levels and self-reported symptoms, changes in cytokines over time, and how baseline cytokine levels may relate to clinically meaningful indicators of change following CBT.
RESULTS: Cytokine/chemokine levels did not significantly change over time. Higher levels of unstimulated IL-1β were associated with significantly worse clinical pain characteristics and greater degree of CBT treatment response.
DISCUSSION: This suggests that individuals with greater degrees of inflammation may derive more benefit from the self-regulation training, pain coping strategies, and cognitive reframing offered in CBT for pain.
METHOD: Participants were randomized to receive either 8-weeks of telemedicine-delivered cognitive-behavioral therapy (CBT) or an active attention control. Six cytokine/chemokines in whole blood plasma (IL-6, IL-8, IL-10, IL-1β, and TNF-α) were assessed in a subset of trial participants at baseline, post-treatment, and at five months. We assessed relationships between baseline plasma inflammatory cytokine levels and self-reported symptoms, changes in cytokines over time, and how baseline cytokine levels may relate to clinically meaningful indicators of change following CBT.
RESULTS: Cytokine/chemokine levels did not significantly change over time. Higher levels of unstimulated IL-1β were associated with significantly worse clinical pain characteristics and greater degree of CBT treatment response.
DISCUSSION: This suggests that individuals with greater degrees of inflammation may derive more benefit from the self-regulation training, pain coping strategies, and cognitive reframing offered in CBT for pain.