Pakistan journal of pharmaceutical sciences · 2026
The hybrid drug delivery system of TCPP-Co, β-cyclodextrin and piroxicam: Spectroscopic characterization, morphological reorganization and controlled release dynamics.
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Khaliq Sohail, Najaf Iqbal Dure, Mazher Mudassar, Iqbal Zafar, Jamil Shahnila
Аннотация
BACKGROUND: Piroxicam, a widely used NSAID, suffers from poor aqueous solubility, limited bioavailability and adverse gastrointestinal effects. Hybrid drug delivery systems combining organic carriers, metal complexes and supramolecular assemblies offer a promising strategy to overcome these limitations.
OBJECTIVES: To design and characterize a multifunctional hybrid drug delivery system integrating cobalt-substituted meso-tetra (4-carboxyphenyl) porphyrin (TCPP-Co), β-cyclodextrin and piroxicam, with the goal of enhancing solubility, structural reorganization and controlled release.
METHODS: The hybrid system was synthesized in ethanol and characterized using UV-Vis, FTIR, ¹H NMR, XRD and SEM. In-vitro release studies were performed in simulated gastric fluid and phosphate buffer, with kinetic modeling applied using Korsmeyer-Peppas, Higuchi and zero-order, first-order and Hixson-Crowell equations.
RESULTS: Spectroscopic analyses confirmed supramolecular interactions through bathochromic shifts, broadened O-H and C=O vibrations and altered proton environments. XRD revealed amorphization, while SEM showed porous, fused morphologies. Drug release kinetics yielded a release exponent n≈0.66, indicating anomalous transport governed by both diffusion and matrix relaxation. The Hixson-Crowell model (R² = 0.993) supported surface erosion, while other models confirmed hybrid release behavior.
CONCLUSION: The TCPP-Co/β-cyclodextrin/piroxicam hybrid system demonstrates enhanced solubility, disrupted crystallinity and controlled release dynamics. This supramolecular assembly validates the potential of metalloporphyrin-cyclodextrin hybrids as advanced NSAID delivery platforms with improved therapeutic performance.
OBJECTIVES: To design and characterize a multifunctional hybrid drug delivery system integrating cobalt-substituted meso-tetra (4-carboxyphenyl) porphyrin (TCPP-Co), β-cyclodextrin and piroxicam, with the goal of enhancing solubility, structural reorganization and controlled release.
METHODS: The hybrid system was synthesized in ethanol and characterized using UV-Vis, FTIR, ¹H NMR, XRD and SEM. In-vitro release studies were performed in simulated gastric fluid and phosphate buffer, with kinetic modeling applied using Korsmeyer-Peppas, Higuchi and zero-order, first-order and Hixson-Crowell equations.
RESULTS: Spectroscopic analyses confirmed supramolecular interactions through bathochromic shifts, broadened O-H and C=O vibrations and altered proton environments. XRD revealed amorphization, while SEM showed porous, fused morphologies. Drug release kinetics yielded a release exponent n≈0.66, indicating anomalous transport governed by both diffusion and matrix relaxation. The Hixson-Crowell model (R² = 0.993) supported surface erosion, while other models confirmed hybrid release behavior.
CONCLUSION: The TCPP-Co/β-cyclodextrin/piroxicam hybrid system demonstrates enhanced solubility, disrupted crystallinity and controlled release dynamics. This supramolecular assembly validates the potential of metalloporphyrin-cyclodextrin hybrids as advanced NSAID delivery platforms with improved therapeutic performance.