Saudi medical journal · 2006
Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Fida Nadia M, Al-Mughales Jamil A, Fadelallah Mohamed F
Аннотация
OBJECTIVE: To investigate whether serum levels of interleukin-1alpha (IL-1alpha), IL-6, tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP) are useful in the diagnosis of neonatal sepsis and meningitis and differentiate them.
METHODS: Blood samples were collected from 35 full term neonates with suspected infection who admitted to the Neonatology Unit, Pediatric Department, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia during January 2002 - June 2003. On the basis of laboratory and bacteriological results, newborns were classified into: sepsis (n = 28), meningitis (n = 7), and healthy controls (n = 16). Sepsis groups were further subdivided according to culture results into: group 1 = proven sepsis (n = 6), group 2 = clinical sepsis (n = 14), and group 3 = possible-infected (n = 8). Serum levels of IL-1alpha, IL-6, TNF-alpha were measured using Enzyme-Linked Immunosorbent Assay while CRP by nephelometer.
RESULTS: In sepsis and meningitis patients, serum levels of CRP (p < 0.01, p < 0.05,) and IL-1alpha (p < 0.001, p < 0.05) were elevated than controls. C-reactive protein levels elevated in proven sepsis (p < 0.001) and IL-1alpha elevated in all subgroups of sepsis (groups 1, 2, 3) compared with (p < 0.05, p < 0.001, p < 0.01) controls. Interleukin-6, TNF-alpha showed no significant differences between studied groups. In sepsis and meningitis, IL-1alpha had a highest sensitivity (89%, 86%), and negative predictive values (89% and 93%).
CONCLUSION: Interleukin-1alpha and CRP increased in neonatal sepsis and meningitis, but cannot differentiate between them. Interleukin-1alpha had a highest sensitivity in prediction of neonatal infection and its assessment may improve accuracy of diagnosis.
METHODS: Blood samples were collected from 35 full term neonates with suspected infection who admitted to the Neonatology Unit, Pediatric Department, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia during January 2002 - June 2003. On the basis of laboratory and bacteriological results, newborns were classified into: sepsis (n = 28), meningitis (n = 7), and healthy controls (n = 16). Sepsis groups were further subdivided according to culture results into: group 1 = proven sepsis (n = 6), group 2 = clinical sepsis (n = 14), and group 3 = possible-infected (n = 8). Serum levels of IL-1alpha, IL-6, TNF-alpha were measured using Enzyme-Linked Immunosorbent Assay while CRP by nephelometer.
RESULTS: In sepsis and meningitis patients, serum levels of CRP (p < 0.01, p < 0.05,) and IL-1alpha (p < 0.001, p < 0.05) were elevated than controls. C-reactive protein levels elevated in proven sepsis (p < 0.001) and IL-1alpha elevated in all subgroups of sepsis (groups 1, 2, 3) compared with (p < 0.05, p < 0.001, p < 0.01) controls. Interleukin-6, TNF-alpha showed no significant differences between studied groups. In sepsis and meningitis, IL-1alpha had a highest sensitivity (89%, 86%), and negative predictive values (89% and 93%).
CONCLUSION: Interleukin-1alpha and CRP increased in neonatal sepsis and meningitis, but cannot differentiate between them. Interleukin-1alpha had a highest sensitivity in prediction of neonatal infection and its assessment may improve accuracy of diagnosis.