Microbial drug resistance (Larchmont, N.Y.) · 2026
First Report of Klebsiella pneumoniae Clinical Isolates Carrying pAmpc Gene ACT-5 with Reduced Sensitivity to Cefepime from Brazil.
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Mello Bianca Azeredo, de Oliveira Macedo Ana Carolina Carvalho, Nunes Nicolle Felix Lima, Miranda Angelica Nogueira, de Sousa Sarah Ribeiro Fernandes, da Silva Wellington Luiz Pontes, de Souza Santos Debora Ribeiro, de Filippis Ivano
Аннотация
Antimicrobial resistance remains a major threat to global public health, with increasing reports of the spread of β-lactamase genes posing significant risks. The number of Enterobacteriaceae harboring plasmid-mediated AmpC enzymes has been rising worldwide, with prevalence rates varying across regions. These β-lactamases are of particular epidemiological concern because they confer resistance to several β-lactam antibiotics, including penicillins, second and third-generation cephalosporins, and monobactams, while isolates typically remain susceptible to cefepime and carbapenems. This study reports, for the first time in Brazil, the detection of the blaACT-5 gene in a Klebsiella pneumoniae isolate recovered from a community-acquired infection clinical sample in Rio de Janeiro, which notably exhibited resistance to both cefepime and carbapenems.