Infection and drug resistance · 2026
Development of a Prediction Model for Severe Pediatric Mycoplasma pneumoniae Pneumonia: A Single-Center Retrospective Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zeng Zeyu, Li Guang, Xu Yanbing, Dong Na, Zhu Danying, Yin Rong, Zhong Haiqin, Yuan Lang, Shen Libing, Ding Guohui, Dong Xiaoyan
Аннотация
BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP) is a common pediatric respiratory infection, with 10-40% of cases progressing to severe MPP (SMPP). Macrolide-resistant Mycoplasma pneumoniae (MRMP) harboring the A2063/2064G mutation is closely associated with disease severity and treatment failure, posing a major clinical challenge. This study aimed to establish an early prediction model for SMPP and explore personalized treatment strategies for children with A2063/2064G-mutated infections.
METHODS: A total of 2381 children diagnosed with MPP at Shanghai Children's Hospital between November 2019 and December 2023 were retrospectively analyzed. Clinical characteristics, laboratory indices, and A2063/2064G mutation status were compared between SMPP and general MPP groups. A predictive model for SMPP was developed using multivariate logistic regression, and its performance was evaluated by receiver operating characteristic (ROC) curve analysis. Medication patterns and length of hospital stay in patients with A2063/2064G mutations were further assessed to formulate personalized treatment strategies.
RESULTS: Of 2381 patients, 71.3% developed SMPP; 46.9% of all cases carried the A2063/2064G mutation, and the mutation rate was significantly higher in the SMPP group (54.7% vs. 27.5%, P < 0.001). The seven-indicator model (fever duration, lactate dehydrogenase (LDH), albumin (ALB), creatine kinase-MB (CK-MB), neutrophil percentage (Neu%), white blood cell (WBC) count and D-dimer) exhibited excellent performance (area under the curve (AUC) = 0.899, 95% confidence interval (CI) = [0.861, 0.937], sensitivity = 0.827, specificity = 0.861). In mutation-positive patients, those requiring tetracyclines (TCs)/fluoroquinolones (FQs) had higher SMPP rates than macrolide antibiotics (MACs)-responsive cases (89.6% vs. 78.0%, P < 0.001). Early TCs/FQs shortened hospital stay (7.30 ± 1.96 vs. 8.38 ± 2.20 days, P < 0.001). The model performed consistently across groups, and age-stratified analysis showed the highest TCs/FQs usage in patients with both mutation and model-predicted SMPP.
CONCLUSION: The prediction model effectively identifies SMPP and guides interventions when combined with mutation status. Early TCs/FQs may benefit children with A2063/2064G-mutated MP when predicted as SMPP.
METHODS: A total of 2381 children diagnosed with MPP at Shanghai Children's Hospital between November 2019 and December 2023 were retrospectively analyzed. Clinical characteristics, laboratory indices, and A2063/2064G mutation status were compared between SMPP and general MPP groups. A predictive model for SMPP was developed using multivariate logistic regression, and its performance was evaluated by receiver operating characteristic (ROC) curve analysis. Medication patterns and length of hospital stay in patients with A2063/2064G mutations were further assessed to formulate personalized treatment strategies.
RESULTS: Of 2381 patients, 71.3% developed SMPP; 46.9% of all cases carried the A2063/2064G mutation, and the mutation rate was significantly higher in the SMPP group (54.7% vs. 27.5%, P < 0.001). The seven-indicator model (fever duration, lactate dehydrogenase (LDH), albumin (ALB), creatine kinase-MB (CK-MB), neutrophil percentage (Neu%), white blood cell (WBC) count and D-dimer) exhibited excellent performance (area under the curve (AUC) = 0.899, 95% confidence interval (CI) = [0.861, 0.937], sensitivity = 0.827, specificity = 0.861). In mutation-positive patients, those requiring tetracyclines (TCs)/fluoroquinolones (FQs) had higher SMPP rates than macrolide antibiotics (MACs)-responsive cases (89.6% vs. 78.0%, P < 0.001). Early TCs/FQs shortened hospital stay (7.30 ± 1.96 vs. 8.38 ± 2.20 days, P < 0.001). The model performed consistently across groups, and age-stratified analysis showed the highest TCs/FQs usage in patients with both mutation and model-predicted SMPP.
CONCLUSION: The prediction model effectively identifies SMPP and guides interventions when combined with mutation status. Early TCs/FQs may benefit children with A2063/2064G-mutated MP when predicted as SMPP.