Epidemiology (Cambridge, Mass.) · 2026
Maternal Exposure to Air Pollution and Fetal Growth: Comparison of Three Exposure Modeling Approaches.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Luo Yana, Rivas Ioar, Foraster Maria, Galmés Toni, Arévalo Gustavo, Barril Lluís, Basagaña Xavier, Bustamante Mariona, Cirach Marta, Domínguez Alan, Jerrett Michael, Gascon Mireia, Lao Jose, Mazarico Edurne, Morillas Àlex, Moreno Teresa, Nieuwenhuijsen Mark J, Persavento Cecilia, Raimbault Bruno, Querol Xavier, Sentís Adrià, Schwartz Joel, Tonne Cathryn, Gómez-Roig María Dolores, Llurba Elisa, Sunyer Jordi, Dadvand Payam
Аннотация
BACKGROUND: Maternal air pollution exposure has been associated with impaired fetal growth, yet most studies have overlooked microenvironmental and personal exposures.
OBJECTIVES: To examine associations between maternal air pollution exposure in key microenvironments (home, workplace, and commuting route) and fetal growth (birth weight and small for gestational age) using three modeling approaches and personal, home-indoor, and home-outdoor monitoring.
METHODS: We used data from 1024 pregnant women in the Barcelona Life Study Cohort (2018-2021). Exposure to nitrogen dioxide, black carbon, and fine particulate matter (PM 2.5 ) and its metallic constituents (copper, iron, and zinc) in each microenvironment was estimated using land-use regression models, dispersion models, and hybrid land-use regression-dispersion models, and combined with time-activity data to estimate total microenvironment exposures. Personal, home-indoor, and home-outdoor nitrogen dioxide concentrations were measured using passive samplers. Associations with birth weight and small for gestational age were evaluated using linear and logistic mixed-effects models.
RESULTS: Higher nitrogen dioxide and black carbon exposure at home and in total microenvironments, estimated by land-use regression, dispersion, and hybrid models, were associated with lower birth weight. Increased black carbon exposure in the workplace (hybrid model) and PM 2.5 exposure both at home (land-use regression model) and in total microenvironments (land-use regression and dispersion models) were also associated with reduced birth weight, as were higher home, workplace, and total microenvironmental exposure to metallic components of PM 2.5 in land-use regression models, although higher workplace PM 2.5 -zinc was associated with higher birth weight in hybrid models. Higher personal and home-outdoor nitrogen dioxide exposure was further associated with reduced birth weight. Similar patterns were observed for small for gestational age.
CONCLUSION: Maternal air pollution exposure was associated with impaired fetal growth. Home-based exposure estimates and short-term nitrogen dioxide measurements may serve as practical exposure proxies during pregnancy.
OBJECTIVES: To examine associations between maternal air pollution exposure in key microenvironments (home, workplace, and commuting route) and fetal growth (birth weight and small for gestational age) using three modeling approaches and personal, home-indoor, and home-outdoor monitoring.
METHODS: We used data from 1024 pregnant women in the Barcelona Life Study Cohort (2018-2021). Exposure to nitrogen dioxide, black carbon, and fine particulate matter (PM 2.5 ) and its metallic constituents (copper, iron, and zinc) in each microenvironment was estimated using land-use regression models, dispersion models, and hybrid land-use regression-dispersion models, and combined with time-activity data to estimate total microenvironment exposures. Personal, home-indoor, and home-outdoor nitrogen dioxide concentrations were measured using passive samplers. Associations with birth weight and small for gestational age were evaluated using linear and logistic mixed-effects models.
RESULTS: Higher nitrogen dioxide and black carbon exposure at home and in total microenvironments, estimated by land-use regression, dispersion, and hybrid models, were associated with lower birth weight. Increased black carbon exposure in the workplace (hybrid model) and PM 2.5 exposure both at home (land-use regression model) and in total microenvironments (land-use regression and dispersion models) were also associated with reduced birth weight, as were higher home, workplace, and total microenvironmental exposure to metallic components of PM 2.5 in land-use regression models, although higher workplace PM 2.5 -zinc was associated with higher birth weight in hybrid models. Higher personal and home-outdoor nitrogen dioxide exposure was further associated with reduced birth weight. Similar patterns were observed for small for gestational age.
CONCLUSION: Maternal air pollution exposure was associated with impaired fetal growth. Home-based exposure estimates and short-term nitrogen dioxide measurements may serve as practical exposure proxies during pregnancy.