Frontiers in veterinary science · 2026
A placebo-controlled study of an herbal compound used for management of lower urinary tract disease in healthy cats.
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Martin Cara E, Bartges Joseph W, English Cook F, Shaw Ashley P, Cox Sherry K
Аннотация
INTRODUCTION: Cystolithiasis is a common cause of feline lower urinary tract signs (LUTS). Urinary relative supersaturation (RSS) can be used to estimate an animal's risk of crystallogenesis and urolithiasis, with high RSS values representing a potential increased risk of calculogenesis. Objectives were to determine whether an herbal supplement when compared with a placebo would decrease urinary excretion of electrolytes and minerals, increase urine volume, and decrease urine RSS for struvite (RSS S), calcium oxalate monohydrate (RSS COM), and calcium oxalate dihydrate (RSS COD).
METHODS: A randomized cross-over study in which 7 healthy male cats aged 10 months to 5 years received a herbal supplement or placebo for 2 weeks, followed by a five-day washout preceding the crossover treatment period. Voided 24-h urine samples were analyzed for pH and concentrations of sodium, potassium, chloride, calcium, phosphorus, magnesium, ammonia, oxalate, and citrate. RSS COM and RSS COD, and urine volumes were compared between supplement and placebo administration.
RESULTS: Six cats were included due to incomplete urine collection from one cat. Urine pH and analyte concentrations, 24-h urinary analyte excretions except phosphorus, which was decreased, and RSS COM and RSS COD did not differ between treatments. Struvite RSS was significantly lower in animals treated with the herbal supplement (p = 0.04).
DISCUSSION: Significantly lower RSS S with the herbal supplement suggests that it may be useful in preventing struvite crystallogenesis and calculogenesis in cats. This may be important for young to middle-aged cats (ages 1-7 years), who are at greatest risk for struvite crystal-associated lower urinary tract disease.
METHODS: A randomized cross-over study in which 7 healthy male cats aged 10 months to 5 years received a herbal supplement or placebo for 2 weeks, followed by a five-day washout preceding the crossover treatment period. Voided 24-h urine samples were analyzed for pH and concentrations of sodium, potassium, chloride, calcium, phosphorus, magnesium, ammonia, oxalate, and citrate. RSS COM and RSS COD, and urine volumes were compared between supplement and placebo administration.
RESULTS: Six cats were included due to incomplete urine collection from one cat. Urine pH and analyte concentrations, 24-h urinary analyte excretions except phosphorus, which was decreased, and RSS COM and RSS COD did not differ between treatments. Struvite RSS was significantly lower in animals treated with the herbal supplement (p = 0.04).
DISCUSSION: Significantly lower RSS S with the herbal supplement suggests that it may be useful in preventing struvite crystallogenesis and calculogenesis in cats. This may be important for young to middle-aged cats (ages 1-7 years), who are at greatest risk for struvite crystal-associated lower urinary tract disease.