American journal of reproductive immunology (New York, N.Y. : 1989) · 2016
Intra-Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth.
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Gomez-Lopez Nardhy, Romero Roberto, Plazyo Olesya, Panaitescu Bogdan, Furcron Amy E, Miller Derek, Roumayah Tamara, Flom Emily, Hassan Sonia S
Аннотация
PROBLEM: Sterile intra-amniotic inflammation is associated with spontaneous preterm labor. Alarmins are proposed to mediate this inflammatory process. The aim of this study was to determine whether intra-amniotic administration of an alarmin, HMGB1, could induce preterm labor/birth.
METHOD OF STUDY: Pregnant B6 mice were intra-amniotically or intraperitoneally injected with HMGB1 or PBS (control). Following injection, the gestational age and the rates of preterm birth and pup mortality were recorded.
RESULTS: Intra-amniotic injection of HMGB1 led to preterm labor/birth [HMGB1 57% (4/7) versus PBS 0% (0/6); P = 0.049) and a high rate of pup mortality at week 1 [HMGB1 60.9 ± 11.7% (25/41) versus PBS 28.9 ± 12.6% (11/38); P = 0.001). Intraperitoneal injection of HMGB1 did not induce preterm labor/birth.
CONCLUSION: Intra-amniotic administration of HMGB1 induces preterm labor/birth.
METHOD OF STUDY: Pregnant B6 mice were intra-amniotically or intraperitoneally injected with HMGB1 or PBS (control). Following injection, the gestational age and the rates of preterm birth and pup mortality were recorded.
RESULTS: Intra-amniotic injection of HMGB1 led to preterm labor/birth [HMGB1 57% (4/7) versus PBS 0% (0/6); P = 0.049) and a high rate of pup mortality at week 1 [HMGB1 60.9 ± 11.7% (25/41) versus PBS 28.9 ± 12.6% (11/38); P = 0.001). Intraperitoneal injection of HMGB1 did not induce preterm labor/birth.
CONCLUSION: Intra-amniotic administration of HMGB1 induces preterm labor/birth.