American journal of veterinary research · 2025
Oral cannabidiol increases thermal threshold in horses without physiologic adverse effects.
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Carroll Anna T, Reed Rachel A, Berghaus Londa J, McNabney Danielle, Knych Heather K
Аннотация
OBJECTIVE: To investigate the effect of cannabidiol (CBD) on thermal and mechanical thresholds and physiologic variables in horses.
METHODS: 6 horses (3 geldings and 3 mares) were enrolled in a prospective, randomized, masked crossover design from March 18 through May 3, 2025. Horses received 3.48 mg/kg CBD oil or placebo (sesame oil) orally every 24 hours for 3 days. Thermal and mechanical thresholds were determined at baseline and 4 and 12 hours after treatment administration on each day. Physiologic variables, including heart rate, respiratory rate, and rectal temperature, were recorded at the same time points. Data were analyzed using a generalized mixed model with significance set at P < .05. A Student t test was used to compare time points.
RESULTS: Thermal threshold was elevated in the CBD group above baseline and placebo on day 2 at 12 hours and on day 3 at 4 hours. There was no effect of treatment on mechanical threshold. Overall least squares mean (95% CI) respiratory rate was 17 (15 to 20) and 18 (15 to 21) breaths/min in the CBD and placebo groups, respectively. There was no effect of treatment on heart rate or rectal temperature.
CONCLUSIONS: CBD provided intermittent antinociception as measured by thermal threshold.
CLINICAL RELEVANCE: Oral administration of CBD appears safe and well tolerated at the dose studied.
METHODS: 6 horses (3 geldings and 3 mares) were enrolled in a prospective, randomized, masked crossover design from March 18 through May 3, 2025. Horses received 3.48 mg/kg CBD oil or placebo (sesame oil) orally every 24 hours for 3 days. Thermal and mechanical thresholds were determined at baseline and 4 and 12 hours after treatment administration on each day. Physiologic variables, including heart rate, respiratory rate, and rectal temperature, were recorded at the same time points. Data were analyzed using a generalized mixed model with significance set at P < .05. A Student t test was used to compare time points.
RESULTS: Thermal threshold was elevated in the CBD group above baseline and placebo on day 2 at 12 hours and on day 3 at 4 hours. There was no effect of treatment on mechanical threshold. Overall least squares mean (95% CI) respiratory rate was 17 (15 to 20) and 18 (15 to 21) breaths/min in the CBD and placebo groups, respectively. There was no effect of treatment on heart rate or rectal temperature.
CONCLUSIONS: CBD provided intermittent antinociception as measured by thermal threshold.
CLINICAL RELEVANCE: Oral administration of CBD appears safe and well tolerated at the dose studied.