Bioorthogonal Reactions for Bioactive Sulfur Species Delivery.

Bioorthogonal chemistry has emerged as a powerful tool for the development of controllable drug delivery systems. Bioactive sulfur species, which participate in complex sulfur signaling pathways, play crucial roles in various physiological and pathological processes. However, achieving precise and controlled administration of these sulfur species remains challenging due to their unique physicochemical properties. Over the past few years, a growing number of delivery strategies, which are triggered by different stimuli, have been developed to enhance our understanding of sulfur signaling. Bioorthogonal triggers not only offer excellent controllability but also provide advantages such as tunability, targeted delivery, and spatiotemporal feedback. This review highlights representative donors that can be activated through bioorthogonal reactions and their applications in studying the biological mechanisms and therapeutic functions of the bioactive sulfur species.