Frontiers in public health · 2026
Can Pakistan achieve the UNGA 70% antibiotic access target? A scoping review of susceptibility data.
СтатьяScoping ReviewНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Benish Fiza, Saleem Zikria, Afzal Shairyar, Arooj Huda, Elrggal Mahmoud E, Haseeb Abdul
Аннотация
BACKGROUND: Antimicrobial resistance (AMR) poses a major public health challenge in Pakistan due to irrational antibiotic use and weak surveillance. The WHO AWaRe framework and United Nations General Assembly (UNGA) declaration urge a 70% global use of Access antibiotics. This scoping review aims to assess whether current susceptibility patterns in Pakistan (2020-2024) support achieving or maintaining the 70% Access target.
METHODS: A PRISMA-ScR-based scoping review identified 2020-2024 studies reporting susceptibility of WHO Access antibiotics in Pakistan. Eligible studies included human clinical isolates tested by standardized antimicrobial susceptibility methods. Weighted pathogen-antibiotic-year-wise susceptibilities were analyzed, along with pathogen-and WHO ATC (anatomical therapeutic chemical classification) class-wise temporal trends.
RESULTS: A total of 74 studies published between 2020 and 2024 were included. Most studies were conducted in Punjab. Overall, the susceptibility of WHO Access antibiotics remained low across major pathogens. S. aureus and Pseudomonas spp showed notable declines, while E. coli has shown variable susceptibility. Among WHO ATC classes, aminoglycosides, beta lactams, and cephalosporins demonstrated low susceptibility.
CONCLUSION: This scoping review revealed that persistently low susceptibility to Access antibiotics in Pakistan challenges the feasibility of the WHO's 70% utilization target. Strengthening surveillance programs is essential to curb AMR and align national efforts with global antibiotic use targets.
METHODS: A PRISMA-ScR-based scoping review identified 2020-2024 studies reporting susceptibility of WHO Access antibiotics in Pakistan. Eligible studies included human clinical isolates tested by standardized antimicrobial susceptibility methods. Weighted pathogen-antibiotic-year-wise susceptibilities were analyzed, along with pathogen-and WHO ATC (anatomical therapeutic chemical classification) class-wise temporal trends.
RESULTS: A total of 74 studies published between 2020 and 2024 were included. Most studies were conducted in Punjab. Overall, the susceptibility of WHO Access antibiotics remained low across major pathogens. S. aureus and Pseudomonas spp showed notable declines, while E. coli has shown variable susceptibility. Among WHO ATC classes, aminoglycosides, beta lactams, and cephalosporins demonstrated low susceptibility.
CONCLUSION: This scoping review revealed that persistently low susceptibility to Access antibiotics in Pakistan challenges the feasibility of the WHO's 70% utilization target. Strengthening surveillance programs is essential to curb AMR and align national efforts with global antibiotic use targets.