Journal of burn care & research : official publication of the American Burn Association · 2026
Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schulman Carl I, Namias Nicholas, Pizano Louis, King Booker T, Hartman Shelley, Mathews Gloria, Lenon Willistine, Kempinski Heidi, Rodriguez-Menocal Luis, Guzman Wellington, Sandoval Arron, Badiavas Evangelos V
Аннотация
Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this Phase 1/2a, first-in-human, open-label study, a 47-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 hours of injury. The treated wound achieved >99% closure within one week, with durable healing for over one year. Scar outcomes improved over 52 weeks, with POSAS scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within one week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.