[Clinico-pharmacological investigation of drugs (domperidone, bromocriptine) influencing human prolactin levels from pregnancy to menopause].

The influence of Motilium (domperidone) tablet on the increase of human prolactin level was investigated in the first and second trimester of pregnancy, in confinement and menopause. It has been stated that domperidone causes the serum prolactin level to increase not only in pregnancy and confinement but in menopause, too, not depending on whether it was spontaneous or it took place after castration. In spite of the fact that domperidone is a dopamine antagonist it increases the FSH level similarly to bromocriptine which is a dopamine agonist, although the serum prolactin level changes in the opposite direction on the effect of the treatment. The decrease of the prolactin level effected by bromocriptine tablet in physiological and pathological galactorrhoea and in hyperprolactinaemia associated with infertility has also been investigated. In addition to the favourable laboratory and clinical results it has been stated that prolactin regulates the changes of the FSH and LH levels both in fertility and menopause.