Current medicinal chemistry · 2026
Comprehensive Exploration of NOTCH2NLA Across Cancers and Its Potential Roles in Prognosis and Immune System Interactions.
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Hu Kezhi, Yan Guohua, Ren Lei, Lv Bo, Su Wei
Аннотация
INTRODUCTION: NOTCH2NLA is a newly identified gene that has recently emerged as a potential key regulator in cancer biology. Although evidence suggests its biological significance, its roles across different cancer types and clinical relevance remain poorly characterized. This study aims to comprehensively investigate the functional value of NOTCH2NLA across multiple cancer types.
MATERIALS AND METHODS: Using advanced bioinformatics tools and publicly available datasets, we analyzed the expression profiles of NOTCH2NLA, assessed its prognostic value for survival outcomes, and examined its role in immune regulation and cancer-related signaling pathways. Genetic alterations and immune infiltration patterns were further explored to evaluate its potential role in tumor development.
RESULTS: NOTCH2NLA exhibited differential expression patterns across various cancer types, with its expression levels significantly correlated with patient survival. Additionally, NOTCH2NLA was found to interact with immune cells, modulate immune infiltration, and participate in key biological processes essential for cancer progression.
DISCUSSION: The findings suggest that NOTCH2NLA plays a multifaceted role in cancer biology, particularly through involvement in immune-related pathways. These results underscore the importance of further exploring how NOTCH2NLA contributes to immune evasion and tumor progression.
CONCLUSION: This study provides comprehensive insights into the pan-cancer functions of NOTCH2NLA and supports its potential as a promising target for personalized cancer therapies.
MATERIALS AND METHODS: Using advanced bioinformatics tools and publicly available datasets, we analyzed the expression profiles of NOTCH2NLA, assessed its prognostic value for survival outcomes, and examined its role in immune regulation and cancer-related signaling pathways. Genetic alterations and immune infiltration patterns were further explored to evaluate its potential role in tumor development.
RESULTS: NOTCH2NLA exhibited differential expression patterns across various cancer types, with its expression levels significantly correlated with patient survival. Additionally, NOTCH2NLA was found to interact with immune cells, modulate immune infiltration, and participate in key biological processes essential for cancer progression.
DISCUSSION: The findings suggest that NOTCH2NLA plays a multifaceted role in cancer biology, particularly through involvement in immune-related pathways. These results underscore the importance of further exploring how NOTCH2NLA contributes to immune evasion and tumor progression.
CONCLUSION: This study provides comprehensive insights into the pan-cancer functions of NOTCH2NLA and supports its potential as a promising target for personalized cancer therapies.