Primary amenorrhoea associated with polycystic ovarian syndrome.

Four patients with primary amenorrhoea associated with polycystic ovarian syndrome were investigated clinically, radiologically, endocrinologically and histologically. The values of FSH and LH were determined in basal conditions, as well as after 100 micrograms of LHRH. The levels of TSH and prolactin were studied before and after TRH stimulation in doses of 200 micrograms. An increase in the basal levels of FSH was established with different responses of the hormone to the LHRH test in the four patients. The values of LH were in the upper normal limits, and the responses of the hormone to the LHRH test were similar to those defined for FSH. The basal levels and the response of TSH and prolactin to TRH were within the norm, with the exception of the first patients, in whom the response of prolactin to TRH stimulation was significantly diminished. The authors discuss the pathogenesis of the disease in connection with the data obtained.