Frontiers in endocrinology · 2026
Hyperuricemia was associated with metabolic response against brain injury instead of metabolism syndrome in Tibet: a cross-sectional analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ren Xue-Wen, Zhang Qiu-Ying, Chang Qing, Hao Ji-Wei, Feng Yu-Xin, Zhu Qing-Lei, Zhang Qing-Hong
Аннотация
BACKGROUND: To determine if hyperuricemia be a metabolic response to prevent brain injury in high-altitude adaption in Tibet.
METHODS: This cross-sectional study enrolled 3 ethnics of males (18-35 yo) from 3 ascending altitudes (n = 1133). Metabolic and brain injury biomarkers were compared among the 3 ethnics, and between the normal (NUA) and high serum uric acid (HUA) groups.
RESULTS: Serum UA levels were simultaneously increased with altitudes in the 3 ethnics (all P < 0.0001), higher in the Hans and Minority than in the Tibetans (both: P < 0.0001). Exclusively in the Hans, xanthine oxidoreductase (XOR) activity was increased (P < 0.0001) whereas fractional excretion of UA was decreased (P < 0.0001) with altitudes, meanwhile, HOMA-IR (P < 0.0001) and HOMA-β (P = 0.017) were invariably reduced, and GLP-1(1-37a) (P < 0.0001) was consistently elevated with the altitudes. Beneficially, arteriosclerosis index was elevated with the altitudes in both the Tibetans and the Minorities rather than in the Hans. The level of pan-axonal marker, PGP 9.5, was elevated with altitudes only in the Hans (P = 0.007), by contrast, the astrocyte marker GFAP were elevated in both the Tibetans (P = 0.0003) and the Minorities (P = 0.038) but not in the Hans (P = 0.13). In comparison of HUA with NUA, while the Hans in shorter stay Lhasa-Yumai showed higher XOR, HOMA-IR, GLP-1(1-37a) and PGP 9.5 levels, PGP9.5 was lower in the Hans in longer stay Lhasa-Tolun; yet both neural biomarkers were elevated in the Tibetans of Lhasa, and tended to decline in Naqu.
CONCLUSION: Hyperuricemia may follow distinctive neuroendocrine mechanism among the 3 ethnics to protect the brain from oxidative stress in Tibet.
METHODS: This cross-sectional study enrolled 3 ethnics of males (18-35 yo) from 3 ascending altitudes (n = 1133). Metabolic and brain injury biomarkers were compared among the 3 ethnics, and between the normal (NUA) and high serum uric acid (HUA) groups.
RESULTS: Serum UA levels were simultaneously increased with altitudes in the 3 ethnics (all P < 0.0001), higher in the Hans and Minority than in the Tibetans (both: P < 0.0001). Exclusively in the Hans, xanthine oxidoreductase (XOR) activity was increased (P < 0.0001) whereas fractional excretion of UA was decreased (P < 0.0001) with altitudes, meanwhile, HOMA-IR (P < 0.0001) and HOMA-β (P = 0.017) were invariably reduced, and GLP-1(1-37a) (P < 0.0001) was consistently elevated with the altitudes. Beneficially, arteriosclerosis index was elevated with the altitudes in both the Tibetans and the Minorities rather than in the Hans. The level of pan-axonal marker, PGP 9.5, was elevated with altitudes only in the Hans (P = 0.007), by contrast, the astrocyte marker GFAP were elevated in both the Tibetans (P = 0.0003) and the Minorities (P = 0.038) but not in the Hans (P = 0.13). In comparison of HUA with NUA, while the Hans in shorter stay Lhasa-Yumai showed higher XOR, HOMA-IR, GLP-1(1-37a) and PGP 9.5 levels, PGP9.5 was lower in the Hans in longer stay Lhasa-Tolun; yet both neural biomarkers were elevated in the Tibetans of Lhasa, and tended to decline in Naqu.
CONCLUSION: Hyperuricemia may follow distinctive neuroendocrine mechanism among the 3 ethnics to protect the brain from oxidative stress in Tibet.