Journal of cardiovascular computed tomography · 2026
High agreement of coronary artery calcification scores between full-dose (6.5 mSv) and reduced-dose (1.5 mSv) chest computed tomography: A retrospective analysis of COPDGene.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Moore Jeff M, Pratte Katherine A, Ferguson Carrie, Casaburi Richard, Iskander Beshoy, Abbasi Asghar, Alapati Prakhyat, Chilukuri Sreya, Narashim Aditya, Budoff Matthew J, Rossiter Harry B
Аннотация
BACKGROUND: Coronary artery calcification (CAC) is a specific feature of atherosclerotic cardiovascular disease. Continued improvements in computed tomography (CT) technology may complicate CAC progression assessment in longitudinal studies that change scanner protocols. Herein, we assessed agreement in CAC measures derived from consecutive non-ECG-gated, chest CT scans performed on the same visit and differing only in radiation dose.
METHODS: Agreement in quantitative CAC scores and CAC score categories were determined from a subset of COPDGene participants (N = 115; age: 66 (9) years; 50% male) who received full- (mean effective radiation dose of 6.5 (1.0) mSv) and reduced- (1.5 (0.7) mSv) dose non-ECG-gated CT chest scans at maximal inspiration during their Phase 2 COPDGene study visit.
RESULTS: CAC measures from the two scanning protocols had high correlation (r = 0.99, 95%CI: 0.99-0.99, p < 0.001), excellent reliability (ICC = 0.98, 95%CI: 0.97-0.99, p = 0.012), and almost perfect agreement (Kw= 0.96, SE = 0.01, 95% CI: 0.95-0.98). With the full-dose protocol as reference, the reduced-dose protocol had high sensitivity and specificity for determining CAC presence, 94.5% (95%CI: 87.6%-98.2%) and 100% (95% CI: 85.8%-100%), respectively. A Bland-Altman analysis revealed a non-significant higher CAC score with the full-dose protocol: mean bias between protocols of 26 with 95% limits of agreement of -185 to 237.
CONCLUSION: CAC scores from non-ECG-gated, chest CT scans are robust to changes in radiation dose at the group level; however, when CAC burden increases, the variability of the CAC score differences increases.
GOV IDENTIFIER: NCT00608764.
METHODS: Agreement in quantitative CAC scores and CAC score categories were determined from a subset of COPDGene participants (N = 115; age: 66 (9) years; 50% male) who received full- (mean effective radiation dose of 6.5 (1.0) mSv) and reduced- (1.5 (0.7) mSv) dose non-ECG-gated CT chest scans at maximal inspiration during their Phase 2 COPDGene study visit.
RESULTS: CAC measures from the two scanning protocols had high correlation (r = 0.99, 95%CI: 0.99-0.99, p < 0.001), excellent reliability (ICC = 0.98, 95%CI: 0.97-0.99, p = 0.012), and almost perfect agreement (Kw= 0.96, SE = 0.01, 95% CI: 0.95-0.98). With the full-dose protocol as reference, the reduced-dose protocol had high sensitivity and specificity for determining CAC presence, 94.5% (95%CI: 87.6%-98.2%) and 100% (95% CI: 85.8%-100%), respectively. A Bland-Altman analysis revealed a non-significant higher CAC score with the full-dose protocol: mean bias between protocols of 26 with 95% limits of agreement of -185 to 237.
CONCLUSION: CAC scores from non-ECG-gated, chest CT scans are robust to changes in radiation dose at the group level; however, when CAC burden increases, the variability of the CAC score differences increases.
GOV IDENTIFIER: NCT00608764.
Предметные рубрики MeSH
AgedFemaleHumansMaleMiddle AgedComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsPredictive Value of TestsPulmonary Disease, Chronic ObstructiveRadiation DosageRadiation ExposureReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexTomography, X-Ray ComputedVascular Calcification