Emergency medicine Australasia : EMA · 2026
The Influence of Hypocalcaemia on Trauma Patients Experiencing Post-Induction Hypotension: A Retrospective Observational Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kwok Andy, Selman Chris, Gumm Kellie, Read David J, Douglas Ned, Bourke Elyssia M
Аннотация
OBJECTIVE: Hypocalcaemia is a common electrolyte disturbance in major trauma patients, particularly those with haemorrhagic shock. Trauma patients are often intubated as part of their care, which can result in post-induction hypotension. We aimed to estimate the effect of hypocalcaemia on post-induction hypotension.
METHODS: We conducted a retrospective observational study of trauma patients ≥ 18 years old intubated in a tertiary Australian Emergency Department between 1st January 2020 and 30th September 2024. Epidemiological and clinical management data were extracted to estimate the effect of hypocalcaemia on outcomes.
RESULTS: Of 478 eligible patients, 151 had available haemodynamic and calcium measurements. Post-induction hypotension occurred in 38/47 (81%) of hypocalcaemic and 69/104 (66%) of non-hypocalcaemic patients. Hypocalcaemia was associated with higher odds of post-induction hypotension (adjusted odds ratio [aOR] 2.15, 95% confidence interval [CI] 0.84-5.51), with considerable uncertainty in this estimate. Hypocalcaemic patients were more likely to receive red blood cells within 15-min post-induction (OR 2.13, 95% CI 1.12-4.04). Minimal differences were observed in cardiac arrest 15-min post-induction (OR 0.65, 95% CI 0.07-5.73) or mortality at discharge (OR 1.00, 95% CI 0.51-1.97).
CONCLUSIONS: Hypocalcaemia may be associated with higher odds of post-induction hypotension in trauma patients; however, our findings require corroboration across a larger multi-centre prospective observational study. If corroborated, a randomised controlled trial is warranted to establish the utility of calcium replacement for the prevention of post-induction hypotension.
METHODS: We conducted a retrospective observational study of trauma patients ≥ 18 years old intubated in a tertiary Australian Emergency Department between 1st January 2020 and 30th September 2024. Epidemiological and clinical management data were extracted to estimate the effect of hypocalcaemia on outcomes.
RESULTS: Of 478 eligible patients, 151 had available haemodynamic and calcium measurements. Post-induction hypotension occurred in 38/47 (81%) of hypocalcaemic and 69/104 (66%) of non-hypocalcaemic patients. Hypocalcaemia was associated with higher odds of post-induction hypotension (adjusted odds ratio [aOR] 2.15, 95% confidence interval [CI] 0.84-5.51), with considerable uncertainty in this estimate. Hypocalcaemic patients were more likely to receive red blood cells within 15-min post-induction (OR 2.13, 95% CI 1.12-4.04). Minimal differences were observed in cardiac arrest 15-min post-induction (OR 0.65, 95% CI 0.07-5.73) or mortality at discharge (OR 1.00, 95% CI 0.51-1.97).
CONCLUSIONS: Hypocalcaemia may be associated with higher odds of post-induction hypotension in trauma patients; however, our findings require corroboration across a larger multi-centre prospective observational study. If corroborated, a randomised controlled trial is warranted to establish the utility of calcium replacement for the prevention of post-induction hypotension.