Analytica chimica acta · 2026
Method development and production of an ambient-stable blood certified reference material for total mercury, methylmercury, and trace elements.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Haraguchi Koichi, Sakamoto Mineshi, Nagasaka Hiromitsu, Uchida Keisuke, Ito Yasunori, Horvat Milena, Rand Matthew D, Cirtiu Ciprian Mihai, Yumvihoze Emmanuel, Kodamatani Hitoshi, Yamamoto Megumi, Iwai-Shimada Miyuki, Duong Hung T, Hishida Naoko, Slyadnev Maxim, Begu Ermira, Klemenčič Polona, Alilović Adna, Iwai Kenta, Nguyen Van Thi, Nakamura Masaaki
Аннотация
BACKGROUND: Certified reference materials (CRMs) for mercury speciation of biological fluids have hitherto been limited to frozen or cold-storage types, which impedes the participation of laboratories in tropical or remote regions. Existing CRMs often do not fully meet user needs, particularly regarding storage stability and concentration relevance.
RESULTS: Using pooled Japanese human blood, we developed a freeze-dried, ambient-stable blood CRM, with certified values of 6.16 μg L-1 for total mercury (THg) and 5.46 μg L-1 for methylmercury (MeHg, as Hg). These concentrations are congruent with median exposure levels in fish-consuming populations (e.g., small island states and riverine Amazonian communities) derived from global biomonitoring data. Homogeneity, stability, and traceability were validated through inter-laboratory comparisons and rigorous uncertainty assessment.
SIGNIFICANCE: This ambient-stable blood CRM broadens global access to high-quality QA/QC of mercury speciation, especially in regions lacking cold-chain infrastructure. It contributes to capacity building under the Minamata Convention and strengthens interlaboratory comparability. Registration in COMAR and international collaborative deployment are under active development, enhancing the global infrastructure for mercury biomonitoring.
RESULTS: Using pooled Japanese human blood, we developed a freeze-dried, ambient-stable blood CRM, with certified values of 6.16 μg L-1 for total mercury (THg) and 5.46 μg L-1 for methylmercury (MeHg, as Hg). These concentrations are congruent with median exposure levels in fish-consuming populations (e.g., small island states and riverine Amazonian communities) derived from global biomonitoring data. Homogeneity, stability, and traceability were validated through inter-laboratory comparisons and rigorous uncertainty assessment.
SIGNIFICANCE: This ambient-stable blood CRM broadens global access to high-quality QA/QC of mercury speciation, especially in regions lacking cold-chain infrastructure. It contributes to capacity building under the Minamata Convention and strengthens interlaboratory comparability. Registration in COMAR and international collaborative deployment are under active development, enhancing the global infrastructure for mercury biomonitoring.